Macrophage polarization: an effective approach to targeted therapy of inflammatory bowel disease

doi:10.1080/14728222.2021.1901079

	Macrophage polarization: an effective approach to targeted therapy of inflammatory bowel disease
	Du, Yaoyao 1,4; Rong, Lan 2; Cong, Yuanhua 3; Shen, Lan 4; Zhang, Ning 1; Wang, Bing 3,4
刊名	EXPERT OPINION ON THERAPEUTIC TARGETS
	2021-03-18
页码	19
关键词	Inflammatory bowel disease macrophage polarization immune regulation targeted therapy
ISSN号	1472-8222
DOI	10.1080/14728222.2021.1901079
通讯作者	Shen, Lan(alansusu@sina.com) ; Zhang, Ning(ningzh18@126.com) ; Wang, Bing(bwang@simm.ac.cn)
英文摘要	Introduction: Inflammatory bowel disease (IBD) is a systemic disease with immune abnormalities that can affect the entire digestive tract. A high percentage of patients with IBD are unresponsive to current pharmacological agents, hence the need exists for novel therapeutic approaches. There is compelling evidence that macrophage polarization plays a key role in the remission of IBD patients and that it could open up future treatment options for patients. Areas covered: This paper highlights the crucial role of macrophage polarization in IBD. The authors shed light on the phenotype and function of macrophages and potential drug targets for polarization regulation. Existing approaches for regulating macrophage polarization are discussed and potential solutions for safety concerns are considered. We performed a literature search on the IBD and macrophage polarization mainly published in PubMed January 2010-July 2020. Expert opinion: Evidence indicates that there are fewer M2 macrophages and a high proportion of M1 macrophages in the intestinal tissues of individuals who are non- responsive to treatment. Regulating macrophage polarization is a potential novel targeted option for IBD treatment. Improved mechanistic insights are required to uncover more precise and effective targets for skewing macrophages into a proper phenotype.
资助项目	Program of Shanghai Committee of Science and Technology, China[17401902300]
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	TAYLOR & FRANCIS LTD
WOS记录号	WOS:000629847400001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/295414]
专题	中国科学院上海药物研究所
通讯作者	Shen, Lan; Zhang, Ning; Wang, Bing
作者单位	1.Shanghai Univ Tradit Chinese Med, Expt Ctr Sci & Technol, 1200 Cailun Rd, Shanghai 201203, Peoples R China 2.Fudan Univ, Dept Digest Dis, Huashan Hosp, Shanghai, Peoples R China 3.Chinese Acad Sci, Ctr Pharmaceut Res, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China 4.Shanghai Univ Tradit Chinese Med, Sch Pharm, 1200 Cailun Rd, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Du, Yaoyao,Rong, Lan,Cong, Yuanhua,et al. Macrophage polarization: an effective approach to targeted therapy of inflammatory bowel disease[J]. EXPERT OPINION ON THERAPEUTIC TARGETS,2021:19.
APA	Du, Yaoyao,Rong, Lan,Cong, Yuanhua,Shen, Lan,Zhang, Ning,&Wang, Bing.(2021).Macrophage polarization: an effective approach to targeted therapy of inflammatory bowel disease.EXPERT OPINION ON THERAPEUTIC TARGETS,19.
MLA	Du, Yaoyao,et al."Macrophage polarization: an effective approach to targeted therapy of inflammatory bowel disease".EXPERT OPINION ON THERAPEUTIC TARGETS (2021):19.