Dynamic modifications of biomacromolecules:mechanism and chemical interventions

	Dynamic modifications of biomacromolecules:mechanism and chemical interventions
	Chu Wang 1; Peng Zou 1; Caiguang Yang 2; Lei Liu 3; Liang Cheng 4; Xiaopeng He 5; Liang Zhang 6; Yan Zhang 7; Hualiang Jiang 2; Peng RChen 1
刊名	中国科学:生命科学英文版
	2019
卷号	62.0 期号:011 页码:1459
关键词	chemical biology biomacromolecule dynamic modification modification analysis chemical intervention
ISSN号	1674-7305
英文摘要	Biological macromolecules(proteins,nucleic acids,polysaccharides,etc.)are the building blocks of life,which constantly undergo chemical modifications that are often reversible and spatial-temporally regulated.These dynamic properties of chemical modifications play fundamental roles in physiological processes as well as pathological changes of living systems.The Major Research Project(MRP)funded by the National Natural Science Foundation of China(NSFC)—"Dynamic modifications of biomacromolecules:mechanism and chemical interventions"aims to integrate cross-disciplinary approaches at the interface of chemistry,life sciences,medicine,mathematics,material science and information science with the following goals:(i)developing specific labeling techniques and detection methods for dynamic chemical modifications of biomacromolecules,(ii)analyzing the molecular mechanisms and functional relationships of dynamic chemical modifications of biomacromolecules,and(iii)exploring biomacromolecules and small molecule probes as potential drug targets and lead compounds.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/294229]
专题	中国科学院上海药物研究所
作者单位	1.College of Chemistry and Molecular Engineering,Peking University 2.中国科学院上海药物研究所 3.Department of Chemistry,Tsinghua University 4.中国科学院化学研究所 5.中华科技大学 6.Department of Pharmacology and Chemical Biology,Shanghai Jiao Tong University School of Medicine 7.National Natural Science Foundation of China
推荐引用方式 GB/T 7714	Chu Wang,Peng Zou,Caiguang Yang,et al. Dynamic modifications of biomacromolecules:mechanism and chemical interventions[J]. 中国科学:生命科学英文版,2019,62.0(011):1459.
APA	Chu Wang.,Peng Zou.,Caiguang Yang.,Lei Liu.,Liang Cheng.,...&Peng RChen.(2019).Dynamic modifications of biomacromolecules:mechanism and chemical interventions.中国科学:生命科学英文版,62.0(011),1459.
MLA	Chu Wang,et al."Dynamic modifications of biomacromolecules:mechanism and chemical interventions".中国科学:生命科学英文版 62.0.011(2019):1459.