Hyaluronic-acid-based beta-cyclodextrin grafted copolymers as biocompatible supramolecular hosts to enhance the water solubility of tocopherol

doi:10.1016/j.ijpharm.2020.119542

	Hyaluronic-acid-based beta-cyclodextrin grafted copolymers as biocompatible supramolecular hosts to enhance the water solubility of tocopherol
	Singh, Parbeen 1,2; Wu, Li 2; Ren, Xiaohong 2; Zhang, Wei 2; Tang, Yan 2; Chen, Yongli 1; Carrier, Andrew 3,4; Zhang, Xu 1,3,4; Zhang, Jiwen 2,5
刊名	INTERNATIONAL JOURNAL OF PHARMACEUTICS
	2020-08-30
卷号	586 页码:7
关键词	Solubility enhancement Hyaluronic acid-beta-cyclodextrin grafted copolymer alpha-Tocopherol Inclusion complex
ISSN号	0378-5173
DOI	10.1016/j.ijpharm.2020.119542
通讯作者	Zhang, Xu(Xu_Zhang@cbu.ca) ; Zhang, Jiwen(jwzhang@simm.ac.cn)
英文摘要	Hyaluronic acid (HA), a common biopolymer found in the extracellular fluid, was grafted with beta-cyclodextrin (beta-CD) to form a composite polymer that could form inclusion complexes with tocopherol (VE), enhancing its water-solubility and serving as a model drug delivery system. Herein, different copolymers were prepared with varying HA:beta-CD ratios and characterized. VE loading capacity was directly correlated with increased beta-CD composition in the polymers and morphological changes were observed upon VE binding. The host materials and their VE inclusion complexes are not cytotoxic, and are thus useful for VE and drug delivery.
资助项目	Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12050307] ; National Key R&D Program of China[2020YFE0201700] ; Post-doctoral Foundation Project of Shenzhen Polytechnic[6019330001K] ; Post-doctoral Foundation Project of Shenzhen Polytechnic[6019330006K] ; Post-doctoral Foundation Project of Shenzhen Polytechnic[6019330007K] ; China Postdoctoral Science Foundation[2019M653139] ; China Postdoctoral Science Foundation[2019M653979] ; Shenzhen Science and Technology Program[GJHZ20180928161212140] ; Guangdong Province Higher Vocational College & School's Pearl River Scholar Funded Scheme (2017) ; Canada Research Chairs program
WOS关键词	VITAMIN-E ; INCLUSION COMPLEX ; IN-VITRO ; PHOTOSTABILITY ; POLYMERS ; MATS
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000557910700010
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/292332]
专题	中国科学院上海药物研究所
通讯作者	Zhang, Xu; Zhang, Jiwen
作者单位	1.Shenzhen Polytech, Postdoctoral Innovat Practice Base, Shenzhen 518055, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, 501 Haike Rd, Shanghai 201203, Peoples R China 3.Cape Breton Univ, Dept Chem, 1250 Grand Lake Rd, Sydney, NS B1P 6L2, Canada 4.Cape Breton Univ, Dept Hlth Sci, 1250 Grand Lake Rd, Sydney, NS B1P 6L2, Canada 5.Natl Inst Food & Drug Control, NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipi, 2 Tiantan Xili, Beijing 100050, Peoples R China
推荐引用方式 GB/T 7714	Singh, Parbeen,Wu, Li,Ren, Xiaohong,et al. Hyaluronic-acid-based beta-cyclodextrin grafted copolymers as biocompatible supramolecular hosts to enhance the water solubility of tocopherol[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2020,586:7.
APA	Singh, Parbeen.,Wu, Li.,Ren, Xiaohong.,Zhang, Wei.,Tang, Yan.,...&Zhang, Jiwen.(2020).Hyaluronic-acid-based beta-cyclodextrin grafted copolymers as biocompatible supramolecular hosts to enhance the water solubility of tocopherol.INTERNATIONAL JOURNAL OF PHARMACEUTICS,586,7.
MLA	Singh, Parbeen,et al."Hyaluronic-acid-based beta-cyclodextrin grafted copolymers as biocompatible supramolecular hosts to enhance the water solubility of tocopherol".INTERNATIONAL JOURNAL OF PHARMACEUTICS 586(2020):7.