Integrative Proteomic Characterization of Human Lung Adenocarcinoma

doi:10.1016/j.cell.2020.05.043

	Integrative Proteomic Characterization of Human Lung Adenocarcinoma
	Xu, Jun-Yu 2; Zhang, Chunchao 3; Wang, Xiang 4; Zhai, Linhui 2; Ma, Yiming 5; Mao, Yousheng 6; Qian, Kun 7; Sun, Changqing 8; Liu, Zhiwei 9; Jiang, Shangwen 2
刊名	CELL
	2020-07-09
卷号	182 期号:1 页码:245-+
ISSN号	0092-8674
DOI	10.1016/j.cell.2020.05.043
通讯作者	Wang, Yi(wangyi@ncpsb.org.cn) ; Li, Jing(jing.li@sjtu.edu.cn) ; He, Fuchu(hefc@nic.bmi.ac.cn) ; Xiao, Ting(xiaot@cicams.ac.cn) ; Tan, Minjia(mjtan@simm.ac.cn)
英文摘要	Genomic studies of lung adenocarcinoma (LUAD) have advanced our understanding of the disease's biology and accelerated targeted therapy. However, the proteomic characteristics of LUAD remain poorly understood. We carried out a comprehensive proteomics analysis of 103 cases of LUAD in Chinese patients. Integrative analysis of proteome, phosphoproteome, transcriptome, and whole-exome sequencing data revealed cancer-associated characteristics, such as tumor-associated protein variants, distinct proteomics features, and clinical outcomes in patients at an early stage or with EGFR and TP53 mutations. Proteome-based stratification of LUAD revealed three subtypes (S-I, S-II, and S-III) related to different clinical and molecular features. Further, we nominated potential drug targets and validated the plasma protein level of HSP 90 beta as a potential prognostic biomarker for LUAD in an independent cohort. Our integrative proteomics analysis enables a more comprehensive understanding of the molecular landscape of LUAD and offers an opportunity for more precise diagnosis and treatment.
资助项目	National Basic Research Program of China (973 Program)[2014CBA02004] ; Natural Science Foundation of China[81821005] ; Natural Science Foundation of China[91753203] ; Natural Science Foundation of China[81872888] ; Natural Science Foundation of China[31901036] ; Natural Science Foundation of China[31871329] ; Natural Science Foundation of China[31700724] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12050406] ; CAMS Innovation Fund for Medical Sciences (CIFMS), China[2016-I2M-1-001] ; National Key Research and Development Program of China[2017YFC0908401] ; Shanghai Sailing Program[19YF1457700] ; Innovative Research Team of High-Level Local Universities in Shanghai[SSMU-ZDCX20181202] ; K. C. Wong Education Foundation ; SA-SIBS Scholarship Program
WOS关键词	CLASS DISCOVERY ; READ ALIGNMENT ; EGFR MUTATION ; NEVER SMOKERS ; COPY NUMBER ; CANCER ; EXPRESSION ; IDENTIFICATION ; BIOMARKER ; TP53
WOS研究方向	Biochemistry & Molecular Biology ; Cell Biology
语种	英语
出版者	CELL PRESS
WOS记录号	WOS:000549184500020
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/292007]
专题	中国科学院上海药物研究所
通讯作者	Wang, Yi; Li, Jing; He, Fuchu; Xiao, Ting; Tan, Minjia
作者单位	1.Fudan Univ, Sch Comp Sci & Technol, Shanghai Key Lab Intelligent Informat Proc, Shanghai 200433, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Beijing Proteome Res Ctr, Natl Ctr Prot Sci Beijing, Beijing Inst Life, State Key Lab Prote, Beijing 102206, Peoples R China 4.Chinese Acad Med Sci & Peking Union Med Coll, Natl Canc Ctr, Dept Etiol & Carcinogenesis,Canc Hosp, State Key Lab Mol Oncol,Natl Clin Res Ctr Canc Ca, Beijing 100021, Peoples R China 5.Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Dept Bioinformat & Biostat, Shanghai 200240, Peoples R China 6.Chinese Acad Med Sci & Peking Union Med Coll, Natl Canc Ctr, Dept Thorac Surg, Natl Clin Res Ctr Canc,Canc Hosp, Beijing 100021, Peoples R China 7.Capital Med Univ, Xuanwu Hosp, Dept Thorac Surg, Beijing 100053, Peoples R China 8.Tianjin Baodi Hosp, Dept Oncol, Tianjin 301800, Peoples R China 9.Univ Chinese Acad Sci, Beijing, Peoples R China 10.Tianjin Med Univ, Dept Oncol, Baodi Clin Coll, Tianjin 301800, Peoples R China
推荐引用方式 GB/T 7714	Xu, Jun-Yu,Zhang, Chunchao,Wang, Xiang,et al. Integrative Proteomic Characterization of Human Lung Adenocarcinoma[J]. CELL,2020,182(1):245-+.
APA	Xu, Jun-Yu.,Zhang, Chunchao.,Wang, Xiang.,Zhai, Linhui.,Ma, Yiming.,...&Tan, Minjia.(2020).Integrative Proteomic Characterization of Human Lung Adenocarcinoma.CELL,182(1),245-+.
MLA	Xu, Jun-Yu,et al."Integrative Proteomic Characterization of Human Lung Adenocarcinoma".CELL 182.1(2020):245-+.