A new bis-gamma-pyrone polypropionate of onchidiol family from marine pulmonate molluskOnchidiumsp

doi:10.1080/14786419.2019.1569010

	A new bis-gamma-pyrone polypropionate of onchidiol family from marine pulmonate molluskOnchidiumsp
	Li, Song-Wei 1,2,3; Cui, Wan-Xiang 1,2,4; Huan, Xia-Juan 2; Gavagnin, Margherita 5; Mollo, Ernesto 5; Miao, Ze-Hong 2; Yao, Li-Gong 1,2; Li, Xu-Wen 1,2; Guo, Yue-Wei 1,2
刊名	NATURAL PRODUCT RESEARCH
	2020-07-17
卷号	34 期号:14 页码:1971-1976
关键词	bis-gamma-pyrone polypropionate X-ray diffraction absolute configuration cytotoxicity marine natural product marine pulmonated mollusk
ISSN号	1478-6419
DOI	10.1080/14786419.2019.1569010
通讯作者	Li, Xu-Wen(xwli@simm.ac.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn)
英文摘要	A new bis-gamma-pyrone polypropionate, 4,16-di-epi-onchidiol (1), along with three known related compounds (2-4) were isolated from the marine pulmonate molluskOnchidiumsp. The structure of compound1was elucidated by extensive spectroscopic analysis and by comparison the NMR data with its stereoisomers2-4, whereas its absolute configuration was determined by the combination of X-ray diffraction analysis and TDDFT-ECD calculation. In bioassay, the isolated compounds exhibited broad cytotoxicity against several cancer cell lines with IC(50)values ranging from 24.6 to 88.5 mu M.
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
出版者	TAYLOR & FRANCIS LTD
WOS记录号	WOS:000547162000003
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/291977]
专题	中国科学院上海药物研究所
通讯作者	Li, Xu-Wen; Guo, Yue-Wei
作者单位	1.Open Studio Druggabil Res Marine Nat Prod, Pilot Natl Lab Marine Sci & Technol Qingdao, Qingdao, Peoples R China 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai, Peoples R China 3.Nanjing Univ Tradit Chinese Med, Nanjing, Peoples R China 4.Binzhou Med Univ, Sch Pharm, Yantai, Peoples R China 5.Consiglio Nazl Ric CNR, Ist Chim Biomol ICB, Naples, Italy
推荐引用方式 GB/T 7714	Li, Song-Wei,Cui, Wan-Xiang,Huan, Xia-Juan,et al. A new bis-gamma-pyrone polypropionate of onchidiol family from marine pulmonate molluskOnchidiumsp[J]. NATURAL PRODUCT RESEARCH,2020,34(14):1971-1976.
APA	Li, Song-Wei.,Cui, Wan-Xiang.,Huan, Xia-Juan.,Gavagnin, Margherita.,Mollo, Ernesto.,...&Guo, Yue-Wei.(2020).A new bis-gamma-pyrone polypropionate of onchidiol family from marine pulmonate molluskOnchidiumsp.NATURAL PRODUCT RESEARCH,34(14),1971-1976.
MLA	Li, Song-Wei,et al."A new bis-gamma-pyrone polypropionate of onchidiol family from marine pulmonate molluskOnchidiumsp".NATURAL PRODUCT RESEARCH 34.14(2020):1971-1976.