Four New Depsides Isolated from Salvia miltiorrhiza and Their Significant Nerve-Protective Activities

doi:10.3390/molecules23123274

	Four New Depsides Isolated from Salvia miltiorrhiza and Their Significant Nerve-Protective Activities
	Jin, Qinghao 1; Hu, Xinyi 1,2; Deng, Yanping 1; Hou, Jinjun 1; Lei, Min 1; Ji, Hongjian 1; Zhou, Jing 1; Qu, Hua 1; Wu, Wanying 1; Guo, Dean 1
刊名	MOLECULES
	2018-12-01
卷号	23 期号:12 页码:8
关键词	Salvia miltiorrhiza depsides nerve-protection HS-SY5Y
ISSN号	1420-3049
DOI	10.3390/molecules23123274
通讯作者	Wu, Wanying(wanyingwu@simm.ac.cn) ; Guo, Dean(daguo@simm.ac.cn)
英文摘要	By investigating of the roots of Salvia miltiorrhiza, which is one of the most widely used Chinese herbs, we used phytochemical methods successfully to obtain twelve depsides: four depsides (1-4) that were previously undescribed, along with eight known ones (5-12). Their structure characteristics were assessed by HR-ESIMS, CD, NMR (H-1, C-13, HSQC, HMBC) data analyses. These four newly isolated compounds (1-4), as well as the other eight compounds (5-12), show extraordinary protective effects on hydrogen peroxide-induced apoptosis in HS-SY5Y cells. Among them, depside 4 and depside 6 displayed more obviously protective effects than others.
资助项目	National Standardization of Traditional Chinese Medicine Project[ZYBZH-C-SH-49] ; National Natural Science Foundation of China[81530095] ; National Standardization Program for Chinese Medicine[ZYBZH-K-LN-01]
WOS关键词	ACID-B ; OXIDATIVE STRESS ; APOPTOSIS ; INJURY ; DAMAGE ; CELLS
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	MDPI
WOS记录号	WOS:000454523000224
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/290880]
专题	中国科学院上海药物研究所
通讯作者	Wu, Wanying; Guo, Dean
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Haike Rd 501, Shanghai 201203, Peoples R China 2.Zhejiang Univ Technol, Inst Bioengn, Hangzhou 310014, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Jin, Qinghao,Hu, Xinyi,Deng, Yanping,et al. Four New Depsides Isolated from Salvia miltiorrhiza and Their Significant Nerve-Protective Activities[J]. MOLECULES,2018,23(12):8.
APA	Jin, Qinghao.,Hu, Xinyi.,Deng, Yanping.,Hou, Jinjun.,Lei, Min.,...&Guo, Dean.(2018).Four New Depsides Isolated from Salvia miltiorrhiza and Their Significant Nerve-Protective Activities.MOLECULES,23(12),8.
MLA	Jin, Qinghao,et al."Four New Depsides Isolated from Salvia miltiorrhiza and Their Significant Nerve-Protective Activities".MOLECULES 23.12(2018):8.