Palladium-Promoted DNA-Compatible Heck Reaction

doi:10.1021/acs.orglett.8b03926

	Palladium-Promoted DNA-Compatible Heck Reaction
	Wang, Xuan 1,2; Sun, Hui 1; Liu, Jiaxiang 1; Zhong, Wenge 2,3; Zhang, Mingqiang 2; Zhou, Hu 1; Dai, Dongcheng 2; Lu, Xiaojie 1
刊名	ORGANIC LETTERS
	2019-02-01
卷号	21 期号:3 页码:719-723
ISSN号	1523-7060
DOI	10.1021/acs.orglett.8b03926
通讯作者	Dai, Dongcheng(ddai@amgen.com) ; Lu, Xiaojie(xjlu@simm.ac.cn)
英文摘要	Optimal conditions for palladium-promoted Heck reaction on DNA were developed with good to excellent conversions. Versatility with either DNA-conjugated styrene/acrylamide or aryl iodide and a broad substrate scope of the corresponding coupling partners were established. Furthermore, robustness of the Heck reaction conditions on single-strand DNA and feasibility for DNA-encoded library production were demonstrated.
资助项目	Amgen
WOS关键词	ENCODED CHEMICAL LIBRARIES ; CATALYZED HECK ; COUPLING REACTIONS ; ACRYLIC-ACID ; SELECTION ; SYSTEM ; WATER
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000457947900030
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/290607]
专题	中国科学院上海药物研究所
通讯作者	Dai, Dongcheng; Lu, Xiaojie
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd,Zhang Jiang Hitech Pk, Shanghai 201203, Peoples R China 2.Amgen Biopharmaceut R&D Shanghai Co Ltd, Amgen Asia R&D Ctr, 4560 Jinke Rd,Bldg 2,13th Floor, Shanghai 201210, Peoples R China 3.Regor Therapeut Inc, 576 Libing Rd,Bldg 2, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Wang, Xuan,Sun, Hui,Liu, Jiaxiang,et al. Palladium-Promoted DNA-Compatible Heck Reaction[J]. ORGANIC LETTERS,2019,21(3):719-723.
APA	Wang, Xuan.,Sun, Hui.,Liu, Jiaxiang.,Zhong, Wenge.,Zhang, Mingqiang.,...&Lu, Xiaojie.(2019).Palladium-Promoted DNA-Compatible Heck Reaction.ORGANIC LETTERS,21(3),719-723.
MLA	Wang, Xuan,et al."Palladium-Promoted DNA-Compatible Heck Reaction".ORGANIC LETTERS 21.3(2019):719-723.