Alstonlarsines A-D, Four Rearranged Indole Alkaloids from Alstonia scholaris

doi:10.1021/acs.orglett.9b00230

	Alstonlarsines A-D, Four Rearranged Indole Alkaloids from Alstonia scholaris
	Zhu, Xu-Xin 1; Fan, Yao-Yue 2; Xu, Lei 2; Liu, Qun-Fang 2; Wu, Jiang-Ping 3; Li, Jing-Ya 2; Li, Jia 2; Gao, Kun 1; Yue, Jian-Min 1,2
刊名	ORGANIC LETTERS
	2019-03-01
卷号	21 期号:5 页码:1471-1474
ISSN号	1523-7060
DOI	10.1021/acs.orglett.9b00230
通讯作者	Li, Jia(jli@simm.ac.cn) ; Gao, Kun(npchem@lzu.edu.cn) ; Yue, Jian-Min(jmyue@simm.ac.cn)
英文摘要	Four indole alkaloids, alstonlarsines A-D (1-4), were isolated from Alstonia scholaris and structurally characterized. Compound 1 possesses a new carbon skeleton with a cage-shaped 9-azatricyclo[4.3.1.0(3,8)]decane motif, and compounds 2-4 feature a rare carbon skeleton that was found in nature for the first time. Plausible biosynthetic routes for 1-4 are proposed. Compound 1 showed DRAK2 inhibitory activity with an IC50 value of 11.65 +/- 0.63 mu M.
资助项目	National Natural Science Foundation of China[21532007] ; National Natural Science Foundation of China[21778027] ; Drug Innovation Major Project of China[2018ZX09711001-001-005] ; Shanghai Commission of Science and Technology[16430711700]
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000460491700049
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/290304]
专题	中国科学院上海药物研究所
通讯作者	Li, Jia; Gao, Kun; Yue, Jian-Min
作者单位	1.Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Ctr Hosp Univ Montreal, Lab Immunol & Cardiovasc Res, 900 Rue St Denis, Montreal, PQ H2X 0A9, Canada
推荐引用方式 GB/T 7714	Zhu, Xu-Xin,Fan, Yao-Yue,Xu, Lei,et al. Alstonlarsines A-D, Four Rearranged Indole Alkaloids from Alstonia scholaris[J]. ORGANIC LETTERS,2019,21(5):1471-1474.
APA	Zhu, Xu-Xin.,Fan, Yao-Yue.,Xu, Lei.,Liu, Qun-Fang.,Wu, Jiang-Ping.,...&Yue, Jian-Min.(2019).Alstonlarsines A-D, Four Rearranged Indole Alkaloids from Alstonia scholaris.ORGANIC LETTERS,21(5),1471-1474.
MLA	Zhu, Xu-Xin,et al."Alstonlarsines A-D, Four Rearranged Indole Alkaloids from Alstonia scholaris".ORGANIC LETTERS 21.5(2019):1471-1474.