Ruthenium(ii)-catalyzed selective C-H bond activation of imidamides and coupling with sulfoxonium ylides: an efficient approach for the synthesis of highly functional 3-ketoindoles

doi:10.1039/c9qo00048h

	Ruthenium(ii)-catalyzed selective C-H bond activation of imidamides and coupling with sulfoxonium ylides: an efficient approach for the synthesis of highly functional 3-ketoindoles
	Wu, Chenglin 1,2,3; Zhou, Jianhui 2,3; He, Guoxue 2,3; Li, Huihui 2,3; Yang, Qiaolan 2,3; Wang, Run 2,3; Zhou, Yu 2,3; Liu, Hong 1,2,3
刊名	ORGANIC CHEMISTRY FRONTIERS
	2019-04-21
卷号	6 期号:8 页码:1183-1188
ISSN号	2052-4129
DOI	10.1039/c9qo00048h
通讯作者	Zhou, Yu(zhouyu@simm.ac.cn) ; Liu, Hong(hliu@simm.ac.cn)
英文摘要	Ruthenium-catalyzed selective C-H bond activation of imidamides and annulation of sulfoxonium ylides were achieved, which afforded a series of 3-ketoindole derivatives in good yields, with good functional group compatibility. The catalytic system generated an indole scaffold by C-N and C-S bond cleavage. This reaction constitutes the first intermolecular coupling of ylides with arenes to afford a 3-ketoindole skeleton by ruthenium-catalyzed C-H activation and annulation cascade.
资助项目	National Natural Science Foundation of China[21672232] ; National Natural Science Foundation of China[21632008] ; National Natural Science Foundation of China[81620108027] ; National S&T Major Projects[2015ZX09103003] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12040217]
WOS关键词	CATALYZED SYNTHESIS ; ASYMMETRIC EPOXIDATION ; INDOLE-DERIVATIVES ; PROPARGYL ALCOHOLS ; 3+2 ANNULATION ; N BOND ; RUTHENIUM ; CYCLIZATION ; ACYLATION ; ANILINES
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000465285100015
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/289953]
专题	中国科学院上海药物研究所
通讯作者	Zhou, Yu; Liu, Hong
作者单位	1.China Pharmaceut Univ, Sch Pharm, Nanjing 210009, Jiangsu, Peoples R China 2.Chinese Acad Sci, CAS Key Lab Receptor Res, Shanghai Inst Mat Med, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Wu, Chenglin,Zhou, Jianhui,He, Guoxue,et al. Ruthenium(ii)-catalyzed selective C-H bond activation of imidamides and coupling with sulfoxonium ylides: an efficient approach for the synthesis of highly functional 3-ketoindoles[J]. ORGANIC CHEMISTRY FRONTIERS,2019,6(8):1183-1188.
APA	Wu, Chenglin.,Zhou, Jianhui.,He, Guoxue.,Li, Huihui.,Yang, Qiaolan.,...&Liu, Hong.(2019).Ruthenium(ii)-catalyzed selective C-H bond activation of imidamides and coupling with sulfoxonium ylides: an efficient approach for the synthesis of highly functional 3-ketoindoles.ORGANIC CHEMISTRY FRONTIERS,6(8),1183-1188.
MLA	Wu, Chenglin,et al."Ruthenium(ii)-catalyzed selective C-H bond activation of imidamides and coupling with sulfoxonium ylides: an efficient approach for the synthesis of highly functional 3-ketoindoles".ORGANIC CHEMISTRY FRONTIERS 6.8(2019):1183-1188.