Cytotoxic Germacrane-Type Sesquiterpene Lactones from the Whole Plant of Carpesium lipskyi

doi:10.1021/acs.jnatprod.8b01004

	Cytotoxic Germacrane-Type Sesquiterpene Lactones from the Whole Plant of Carpesium lipskyi
	Zhu, Nan-Lin 5,7; Tang, Chunping 2,5; Xu, Chenghui 6; Ke, Chang-Qiang 2,5; Lin, Ge 2; Jenis, Janar 3; Yao, Sheng 2,5; Liu, Hongchun 6; Ye, Yang 1,2,4,5,7
刊名	JOURNAL OF NATURAL PRODUCTS
	2019-04-01
卷号	82 期号:4 页码:919-927
ISSN号	0163-3864
DOI	10.1021/acs.jnatprod.8b01004
通讯作者	Liu, Hongchun(hchliu@simm.ac.cn) ; Ye, Yang(yye@mail.shcnc.ac.cn)
英文摘要	Ten new sesquiterpene lactones, carlipsines A J (1-10), and 12 known analogues (11-22) were isolated from the whole plant of Carpesium lipskyi. Their structures were elucidated by using 1D and 2D NMR and HRESIMS analyses, and their absolute configurations were confirmed by X-ray diffraction studies. All compounds were identified as germacranolides with diverse substructural features. Compounds 1-4 are 2,5-hemiacetal-linked germacranolides. Compounds 5 and 6 possess a 1,2-epoxy moiety. Compounds 7 and 8 represent unusual 1,5-hemiacetal-linked germacranolides. Compounds 9 and 10 contain a tetrahydrofuran unit with the oxygen atom bridging C-1 and C-8. Compounds 6, 7, 8, 19, 20, 21, and 22 showed cytotoxicity against HL-60 and A-549 cell lines with IC50 values ranging from 2.8 to 10.3 mu M.
资助项目	National Science & Technology Major Project of China Key New Drug Creation and Manufacturing Program[2015ZX09103002] ; National Natural Science Foundation of China[81573305] ; National Natural Science Foundation of China[81673327] ; International Partnership Program of Chinese Academy of Sciences[153631KYSB20160004] ; International Partnership Program of Chinese Academy of Sciences[153631KYSB20170043] ; Collaborative Innovation Center of Southwest Ethnic Medicine, Guangxi Normal University[CICSEM 2017-A]
WOS关键词	STRUCTURE ELUCIDATION
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000466442100027
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/289881]
专题	中国科学院上海药物研究所
通讯作者	Liu, Hongchun; Ye, Yang
作者单位	1.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201203, Peoples R China 2.SIMM CUHK Joint Res Lab Promoting Globalizat Trad, Shanghai 201203, Peoples R China 3.Al Farabi Kazakh Natl Univ, Res Ctr Med Plants, Al Farabi Ave 71, Alma Ata 050040, Kazakhstan 4.Guangxi Normal Univ, Collaborat Innovat Ctr Southwest Ethn Med, Guiling 541001, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai 201203, Peoples R China 6.Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, State Key Lab Drug Res, Shanghai 201203, Peoples R China 7.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Nan-Lin,Tang, Chunping,Xu, Chenghui,et al. Cytotoxic Germacrane-Type Sesquiterpene Lactones from the Whole Plant of Carpesium lipskyi[J]. JOURNAL OF NATURAL PRODUCTS,2019,82(4):919-927.
APA	Zhu, Nan-Lin.,Tang, Chunping.,Xu, Chenghui.,Ke, Chang-Qiang.,Lin, Ge.,...&Ye, Yang.(2019).Cytotoxic Germacrane-Type Sesquiterpene Lactones from the Whole Plant of Carpesium lipskyi.JOURNAL OF NATURAL PRODUCTS,82(4),919-927.
MLA	Zhu, Nan-Lin,et al."Cytotoxic Germacrane-Type Sesquiterpene Lactones from the Whole Plant of Carpesium lipskyi".JOURNAL OF NATURAL PRODUCTS 82.4(2019):919-927.