Research Progress in Tumor Therapy Targeting Plasminogen Activator Inhibitor-1 | |
Liu Ji-Hao1,4; Tang Shu-Zhi1,4; Hu Li-Hong3; Huang Ming-Dong2; Chen Zhuo1,4 | |
刊名 | PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS |
2019-07-01 | |
卷号 | 46期号:7页码:663-672 |
关键词 | tumor therapy plasminogen activator inhibitor-1 tumor microenvironment |
ISSN号 | 1000-3282 |
DOI | 10.16476/j.pibb.2019.0011 |
通讯作者 | Huang Ming-Dong(mhuang@fjirsm.ac.cn) ; Chen Zhuo(zchen@fjirsm.ac.cn) |
英文摘要 | Cancer is a serious disease that endangers human health. Solid tumors are surrounded by extracellular matrix, infiltrated immune cells, and the secretum of surrounding mesenchymal cells. The tumor microenvironment plays a key role in tumorigenesis, tumor growth, and resistance to antineoplastic therapy. Plasminogen activator inhibitor-1 (PAI-1) is an important regulatory factor in tumor microenvironment. PAI-1 not only functions as a key constitution with tissue-type plasminogen activators (tPA) in regulating fibrinolytic activity, but also participates in invasion, infiltration and migration of tumor. In this paper, the structure and function of PAI-1 and its significance in tumor microenvironment in recent years are reviewed. It is considered that PAI-1 may be an important target for anti-cancer therapy. At the same time, the latest research results of PAI-1 inhibitors in the field of anticancer were analyzed, and the potential application value of PAI-1 inhibitors was demonstrated. |
资助项目 | National Key R&D Program of China[2017YFE0103200] ; National Natural Science Foudation of China[31370737] ; National Natural Science Foudation of China[81572944] ; CAS/SAFEA International Partnership Program for Creative Research Teams ; High -Level Entrepreneurship and Innovation Talents Projects in Fujian Province[[2018]8-1] |
WOS关键词 | PAI-1 INHIBITOR ; ENDOTHELIAL-CELLS ; BINDING-SITE ; CANCER ; ANTAGONIST ; EXPRESSION ; MECHANISM ; TYPE-1 ; GENE ; IDENTIFICATION |
WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
语种 | 英语 |
出版者 | CHINESE ACAD SCIENCES, INST BIOPHYSICS |
WOS记录号 | WOS:000477784600003 |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.183/handle/2S10ELR8/289141] |
专题 | 中国科学院上海药物研究所 |
通讯作者 | Huang Ming-Dong; Chen Zhuo |
作者单位 | 1.Chinese Acad Sci, Fujian Inst Res Struct Matter, State Key Lab Struct Chem, Fuzhou 350002, Fujian, Peoples R China 2.Fuzhou Univ, Coll Chem, Fuzhou 350116, Fujian, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
推荐引用方式 GB/T 7714 | Liu Ji-Hao,Tang Shu-Zhi,Hu Li-Hong,et al. Research Progress in Tumor Therapy Targeting Plasminogen Activator Inhibitor-1[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2019,46(7):663-672. |
APA | Liu Ji-Hao,Tang Shu-Zhi,Hu Li-Hong,Huang Ming-Dong,&Chen Zhuo.(2019).Research Progress in Tumor Therapy Targeting Plasminogen Activator Inhibitor-1.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,46(7),663-672. |
MLA | Liu Ji-Hao,et al."Research Progress in Tumor Therapy Targeting Plasminogen Activator Inhibitor-1".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 46.7(2019):663-672. |
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