Ultrafine Silver Nanoparticles Embedded in Cyclodextrin Metal-Organic Frameworks with GRGDS Functionalization to Promote Antibacterial and Wound Healing Application

doi:10.1002/smll.201901065

	Ultrafine Silver Nanoparticles Embedded in Cyclodextrin Metal-Organic Frameworks with GRGDS Functionalization to Promote Antibacterial and Wound Healing Application
	Shakya, Shailendra 1,2; He, Yaping 1,2; Ren, Xiaohong 1; Guo, Tao 1; Maharjan, Abi 1,2; Luo, Ting 1,3; Wang, Tingting 4; Dhakhwa, Ramesh 5; Regmi, Balmukunda 6; Li, Haiyan 1
刊名	SMALL
	2019-07-01
卷号	15 期号:27 页码:13
关键词	antibacterial cyclodextrin metal-organic frameworks silver nanoparticles stability wound healing
ISSN号	1613-6810
DOI	10.1002/smll.201901065
通讯作者	Li, Haiyan(lihaiyan821005@163.com) ; Gref, Ruxandra(ruxandra.gref@u-psud.fr) ; Zhang, Jiwen(jwzhang@simm.ac.cn)
英文摘要	The challenge of bacterial infection increases the risk of mortality and morbidity in acute and chronic wound healing. Silver nanoparticles (Ag NPs) are a promising new version of conventional antibacterial nanosystem to fight against the bacterial resistance in concern of the drug discovery void. However, there are several challenges in controlling the size and colloidal stability of Ag NPs, which readily aggregate or coalesce in both solid and aqueous state. In this study, a template-guided synthesis of ultrafine Ag NPs of around 2 nm using water-soluble and biocompatible gamma-cyclodextrin metal-organic frameworks (CD-MOFs) is reported. The CD-MOF based synthetic strategy integrates AgNO3 reduction and Ag NPs immobilization in one pot achieving dual functions of reduced particle size and enhanced stability. Meanwhile, the synthesized Ag NPs are easily dispersible in aqueous media and exhibit effective bacterial inhibition. The surface modification of cross-linked CD-MOF particles with GRGDS peptide boosts the hemostatic effect that further enhances wound healing in synergy with the antibacterial effect. Hence, the strategy of ultrafine Ag NPs synthesis and immobilization in CD-MOFs together with GRGDS modification holds promising potential for the rational design of effective wound healing devices.
资助项目	Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12050307] ; National Science and Technology Major Projects for the Major New Drugs Innovation and Development[2018ZX09721002-009] ; Research Foundation of the Shanghai Institute of Materia Medica[CASIMM0120182001] ; CAS-TWAS President's Fellowship Program
WOS关键词	CONTACT-ANGLE MEASUREMENT ; SIZE ; STABILITY ; SHAPE ; PARTICLES ; GAMMA ; IONS ; FATE
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000477930000003
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/289044]
专题	中国科学院上海药物研究所
通讯作者	Li, Haiyan; Gref, Ruxandra; Zhang, Jiwen
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China 3.Jiangxi Univ Tradit Chinese Med, Minist Educ, Key Lab Modern Preparat TCM, Nanchang 330004, Jiangxi, Peoples R China 4.Jilin Univ, Bethune Hosp 1, Res Inst Translat Med, Changchun 130061, Jilin, Peoples R China 5.Kathmandu Univ, Kathmandu Med Coll, Kathmandu 44600, Nepal 6.Tribhuvan Univ, Inst Med, Maharajgung Med Campus, Kathmandu 44606, Nepal 7.Univ Paris Saclay, Univ Paris Sud, Inst Sci Mol Orsay, UMR CNRS 8214, F-91400 Orsay, France
推荐引用方式 GB/T 7714	Shakya, Shailendra,He, Yaping,Ren, Xiaohong,et al. Ultrafine Silver Nanoparticles Embedded in Cyclodextrin Metal-Organic Frameworks with GRGDS Functionalization to Promote Antibacterial and Wound Healing Application[J]. SMALL,2019,15(27):13.
APA	Shakya, Shailendra.,He, Yaping.,Ren, Xiaohong.,Guo, Tao.,Maharjan, Abi.,...&Zhang, Jiwen.(2019).Ultrafine Silver Nanoparticles Embedded in Cyclodextrin Metal-Organic Frameworks with GRGDS Functionalization to Promote Antibacterial and Wound Healing Application.SMALL,15(27),13.
MLA	Shakya, Shailendra,et al."Ultrafine Silver Nanoparticles Embedded in Cyclodextrin Metal-Organic Frameworks with GRGDS Functionalization to Promote Antibacterial and Wound Healing Application".SMALL 15.27(2019):13.