Procyanidin C1, a Component of Cinnamon Extracts, Is a Potential Insulin Sensitizer That Targets Adipocytes

doi:10.1021/acs.jafc.9b02932

	Procyanidin C1, a Component of Cinnamon Extracts, Is a Potential Insulin Sensitizer That Targets Adipocytes
	Sun, Peng 1,2; Li, Kai 2; Wang, Ting 1; Ji, Jun 1; Wang, Yan 2; Chen, Kai-Xian 1,3; Jia, Qi 3; Li, Yi-Ming 3; Wang, He-Yao 1
刊名	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
	2019-08-14
卷号	67 期号:32 页码:8839-8846
关键词	cinnamon extracts B-type procyanidin 3T3-L1 adipocytes insulin sensitivity glucose uptake
ISSN号	0021-8561
DOI	10.1021/acs.jafc.9b02932
通讯作者	Li, Yi-Ming(ymlius@163.com) ; Wang, He-Yao(hywang@simm.ac.cn)
英文摘要	Natural products are one of the main sources for discovering new lead compounds. We previously reported that cinnamon extract has a promising effect in regulating lipid tissue volume and insulin sensitivity in vivo. However, its effective component and the underlying mechanism are not known. In the present study, we analyzed the effect of different components of cinnamon on regulating insulin sensitivity in 3T3-L1 adipocytes. Functional assay revealed that, of the six major components of cinnamon extracts, the B-type procyanidin, procyanidin C1, improves the differentiation of 3T3-L1 cells (TG content: 1.10 +/- 0.09 mM at a dosage of 25 mu M vs 0.67 +/- 0.02 mM in vehicle group, p < 0.001) and promotes insulin-induced glucose uptake (8.58 +/- 1.43 at a dosage of 25 mu M vs 3.05 +/- 1.24 in vehicle group, p < 0.001). Mechanism studies further suggested that procyanidin C1 activates the AKT-eNOS pathway, thus up-regulating glucose uptake and enhancing insulin sensitivity in mature adipocytes. Taken together, our study identified B-type procyanidin C1, a component of cinnamon extract, that stimulates preadipocyte differentiation and acts as a potential insulin action enhancer through the AKT-eNOS pathway in mature adipocytes.
资助项目	National Natural Science Foundation of China[81773791] ; National Natural Science Foundation of China[81473262] ; National Natural Science Foundation of China[81603169] ; National Natural Science Foundation of China[81600598] ; Personalized Medicines-Molecular Signature -based Drug Discovery and Development, Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12040336] ; Natural Science Foundation of Jiangsu Province[BK20161027] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China[2018ZX09711002-002-007]
WOS关键词	PANCREATIC BETA-CELLS ; SUBCUTANEOUS ADIPOSE-TISSUE ; NITRIC-OXIDE ; GLUCOSE-UPTAKE ; DIFFERENTIATION ; TRIMER ; ACTIVATION ; ADIPOGENESIS ; PATHWAY ; PROTEIN
WOS研究方向	Agriculture ; Chemistry ; Food Science & Technology
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000481563600013
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/288904]
专题	中国科学院上海药物研究所
通讯作者	Li, Yi-Ming; Wang, He-Yao
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 2.Nanjing Med Univ, Key Lab Human Funct Genom Jiangsu Prov, Nanjing 211166, Jiangsu, Peoples R China 3.Shanghai Univ Tradit Chinese Med, Sch Pharm, 1200 Cailun Rd, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Sun, Peng,Li, Kai,Wang, Ting,et al. Procyanidin C1, a Component of Cinnamon Extracts, Is a Potential Insulin Sensitizer That Targets Adipocytes[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2019,67(32):8839-8846.
APA	Sun, Peng.,Li, Kai.,Wang, Ting.,Ji, Jun.,Wang, Yan.,...&Wang, He-Yao.(2019).Procyanidin C1, a Component of Cinnamon Extracts, Is a Potential Insulin Sensitizer That Targets Adipocytes.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,67(32),8839-8846.
MLA	Sun, Peng,et al."Procyanidin C1, a Component of Cinnamon Extracts, Is a Potential Insulin Sensitizer That Targets Adipocytes".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 67.32(2019):8839-8846.