depsidesaltsfromsalviamiltiorrhizaimprovemyocardialmicroperfusioninratsusinglaserdopplerflowmetry1

	depsidesaltsfromsalviamiltiorrhizaimprovemyocardialmicroperfusioninratsusinglaserdopplerflowmetry1
	Xiaofen LI; Yiping WANG
刊名	actapharmacologicasinica
	2007
卷号	28 期号:6 页码:789
关键词	lithospermate B myocardial microperfu-sion laser Doppler flowmetry cardiac output ultrasonic Doppler flowmetry
ISSN号	1671-4083
英文摘要	Aim: To investigate the effects of depside salts from Salvia miltiorrhiza on myocardial microperfusion and systemic hemodynamics in open-chest anaesthetized Sprague-Dawley rats. Methods: Myocardial microperfusion was measured by laser Doppler flowmetry with a needle probe; cardiac output (CO) was determined using ultrasonic Doppler flowmetry. Other hemodynamic parameters, including femoral artery blood pressure, cardiac inotropy, and systemic vascular resistance (SVR) were simultaneously recorded by the PowerLab system. Results: Intravenous administration of S miltiorrhiza depside salts resulted in a significant immediate increase in CO and cardiac inotropy, but a fall in SVR. S miltiorrhiza depside salts (30 mg/kg and 60 mg/kg) promoted cardiac index (CI) by 12.2%±6.3% (P<0.01 vs baseline) and 20.1%±3.5% (P<0.01), respectively. Myocardial microperfusion maxi mally i n cr eased by 6.3%±2.9% (P<0.01) an d 9.6%±4.0% (P<0.01) for 30 mg/kg and 60 mg/kg S miltiorrhiza depside salts, respectively. Conclusion: These results indicated that S miltiorrhiza depside salts improved myocardial micro-perfusion, as well as CO.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/286092]
专题	中国科学院上海药物研究所
作者单位	中国科学院上海药物研究所
推荐引用方式 GB/T 7714	Xiaofen LI,Yiping WANG. depsidesaltsfromsalviamiltiorrhizaimprovemyocardialmicroperfusioninratsusinglaserdopplerflowmetry1[J]. actapharmacologicasinica,2007,28(6):789.
APA	Xiaofen LI,&Yiping WANG.(2007).depsidesaltsfromsalviamiltiorrhizaimprovemyocardialmicroperfusioninratsusinglaserdopplerflowmetry1.actapharmacologicasinica,28(6),789.
MLA	Xiaofen LI,et al."depsidesaltsfromsalviamiltiorrhizaimprovemyocardialmicroperfusioninratsusinglaserdopplerflowmetry1".actapharmacologicasinica 28.6(2007):789.