hypoxiainducesuniversalbutdifferentialdrugresistanceandimpairsanticancermechanismsof5fluorouracilinhepatomacells

doi:10.1038/aps.2017.79

	hypoxiainducesuniversalbutdifferentialdrugresistanceandimpairsanticancermechanismsof5fluorouracilinhepatomacells
	Li Jingqiu 1; Wu Xian 1; Gan Lu 1; Yang Xiangliang 1; Mlao Zehong 2
刊名	actapharmacologicasinica
	2017
卷号	38 期号:12 页码:1642
关键词	hepatocellular carcinoma hypoxia 5-fluorouracil sorafenib drug resistance
ISSN号	1671-4083
DOI	10.1038/aps.2017.79
英文摘要	Hepatocellular carcinoma (HCC) is one of the most refractory cancers. The mechanisms by which hypoxia further aggravates therapeutic responses of advanced HCC to anticancer drugs remain to be clarified. Here, we report that hypoxia (1% O_2) caused 2.55-489.7-fold resistance to 6 anticancer drugs (sorafenib, 5-fluorouracil 5-FU
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/285728]
专题	中国科学院上海药物研究所
作者单位	1.华中科技大学 2.中国科学院上海药物研究所
推荐引用方式 GB/T 7714	Li Jingqiu,Wu Xian,Gan Lu,et al. hypoxiainducesuniversalbutdifferentialdrugresistanceandimpairsanticancermechanismsof5fluorouracilinhepatomacells[J]. actapharmacologicasinica,2017,38(12):1642.
APA	Li Jingqiu,Wu Xian,Gan Lu,Yang Xiangliang,&Mlao Zehong.(2017).hypoxiainducesuniversalbutdifferentialdrugresistanceandimpairsanticancermechanismsof5fluorouracilinhepatomacells.actapharmacologicasinica,38(12),1642.
MLA	Li Jingqiu,et al."hypoxiainducesuniversalbutdifferentialdrugresistanceandimpairsanticancermechanismsof5fluorouracilinhepatomacells".actapharmacologicasinica 38.12(2017):1642.