stressmediatedp38activationpromotessomaticcellreprogramming

	stressmediatedp38activationpromotessomaticcellreprogramming
	Xu Xinxiu 1; Wang Quan 2; Long Yuan 2; Zhang Ru 1; Wei Xiaoyuan 1; Xing Mingzhe 1; Gu Haifeng 2; Xie Xin 1
刊名	cellresearch
	2013
卷号	23 期号:1 页码:131
关键词	induced pluripotent stem cells iPS hyperosmosis NaCl stress p38 reprogramming
ISSN号	1001-0602
英文摘要	Environmental stress-mediated adaptation plays essential roles in the evolution of life. Cellular adaptation mechanisms usually involve the regulation of chromatin structure, transcription, mRNA stability and translation, which eventually lead to efficient changes in gene expression. Global epigenetic change is also involved in the reprogramming of somatic cells into induced pluripotent stem (iPS) cells by defined factors. Here we report that environmental stress such as hyperosmosis not only facilitates four factor-mediated reprogramming, but also enhances two or one factor-induced iPS cell generation. Hyperosmosis-induced p38 activation plays a critical role in this process. Constitutive active p38 mimics the positive effect of hyperosmosis, while dominant negative p38 and p38 inhibitor block the effect of hyperosmosis. Further study indicates stress-mediated p38 activation may promote reprogramming by reducing the global DNA methylation level and enhancing the expression of pluripotency genes. Our results demonstrate how simple environmental stress like hyperosmosis helps to alter the fate of cells via intracellular signaling and epigenetic modulation.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/284098]
专题	中国科学院上海药物研究所
作者单位	1.同济大学 2.中国科学院上海药物研究所
推荐引用方式 GB/T 7714	Xu Xinxiu,Wang Quan,Long Yuan,et al. stressmediatedp38activationpromotessomaticcellreprogramming[J]. cellresearch,2013,23(1):131.
APA	Xu Xinxiu.,Wang Quan.,Long Yuan.,Zhang Ru.,Wei Xiaoyuan.,...&Xie Xin.(2013).stressmediatedp38activationpromotessomaticcellreprogramming.cellresearch,23(1),131.
MLA	Xu Xinxiu,et al."stressmediatedp38activationpromotessomaticcellreprogramming".cellresearch 23.1(2013):131.