chemicalinterventiononstaphylococcusaureusvirulence

doi:10.1002/cjoc.201800470

	chemicalinterventiononstaphylococcusaureusvirulence
	Zhou Linlin; Yang Caiguang
刊名	chinesejournalofchemistry
	2019
卷号	37 期号:2 页码:183
关键词	BACTERIAL VIRULENCE ALPHA-TOXIN POTENT INHIBITORS SURFACE-PROTEINS GENE-EXPRESSION CLPP PROTEASE SORTASE BIOSYNTHESIS DISCOVERY STAPHYLOXANTHIN
ISSN号	1001-604X
DOI	10.1002/cjoc.201800470
英文摘要	Resistance to conventional antibiotics has raised worldwide attention. Notably, Methicillin-resistant Staphylococcus aureus (MRSA) has become one of the most life-threatening health concerns. Although effective against bacterial infections, conventional antibiotics have also showed a series of side effects such as gut microbiota imbalance. An alternative is in urgent need in order to combat bacterial infections. Antivirulence represents a new approach to circumvent these shortcomings, which focuses on disarming the "weapons" for pathogenicity without much selective pressure on bacterial survival. In this review, we place emphasis on the chemical modulation of biosynthesis, assembly, function and the regulation of some major virulence factors in S. aureus, which we hope will help the development of antivirulence modulators.
资助项目	[National Natural Science Foundation of China] ; [Program of Shanghai Academic Research Leader]
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/284041]
专题	中国科学院上海药物研究所
作者单位	中国科学院上海药物研究所
推荐引用方式 GB/T 7714	Zhou Linlin,Yang Caiguang. chemicalinterventiononstaphylococcusaureusvirulence[J]. chinesejournalofchemistry,2019,37(2):183.
APA	Zhou Linlin,&Yang Caiguang.(2019).chemicalinterventiononstaphylococcusaureusvirulence.chinesejournalofchemistry,37(2),183.
MLA	Zhou Linlin,et al."chemicalinterventiononstaphylococcusaureusvirulence".chinesejournalofchemistry 37.2(2019):183.