Ultramild One-Step Encapsulating Method as a Modular Strategy for Protecting Humidity-Susceptible Metal-Organic Frameworks Achieving Tunable Drug Release Profiles

doi:10.1021/acsbiomaterials.9b01233

	Ultramild One-Step Encapsulating Method as a Modular Strategy for Protecting Humidity-Susceptible Metal-Organic Frameworks Achieving Tunable Drug Release Profiles
	Zhou, Yixian 2; Luo, Sulan 2; Niu, Boyi 2; Wu, Biyuan 2; Fu, Jintao 2; Zhao, Yiting 2; Singh, Vikramjeet 2; Lu, Chao 2; Quan, Guilan 2; Pan, Xin 2
刊名	ACS BIOMATERIALS SCIENCE & ENGINEERING
	2019-10-01
卷号	5 期号:10 页码:5180-5188
关键词	metal-organic frameworks hydrolytic stability composite microparticles controlled drug delivery
ISSN号	2373-9878
DOI	10.1021/acsbiomaterials.9b01233
通讯作者	Quan, Guilan(quanglan@mail.sysu.edu.cn) ; Wu, Chuanbin(wuchuanb@mail.sysu.edu.cn)
英文摘要	Metal organic frameworks (MOFs), composed of metal ions or clusters and organic ligands, have emerged as a new class of porous materials. However, water instability of many MOFs has impeded their further applications. Herein, an ultramild one-step encapsulating method has been developed by incorporating gamma-cyclodextrin-based MOFs (CD-MOFs) into hydrophobic ethylcellulose to fabricate composite microparticles for ideal hydrolytic stability. The whole process can be completed at ambient temperature by the novel ultrafine particle processing system in several minutes without any purification or drying steps. The composite microparticles well retained their morphology and crystal structure of CD-MOFs even after being exposed to extreme humid environment for 30 d. The composite microparticles were further exploited for drug delivery. The composite microparticles not only exhibited sustained and tunable pH-dependent drug release profiles in simulated physiological conditions but also reduced cell toxicity compared with drug-loaded CD-MOFs, which demonstrated that the composite microparticles were promising as drug carriers. In summary, this study developed a modular strategy for protecting humidity-susceptible MOFs with controlled release profiles, which is expected to open up a new avenue to expand their applications in the biomedical field.
资助项目	National Natural Science Funds of China[81803466] ; Natural Science Fund Project of Guangdong Province[2016A030312013] ; Natural Science Fund Project of Guangdong Province[2018A030310095] ; 111 project[B16047]
WOS关键词	MOISTURE-RESISTANT ; MOF ; STABILITY ; WATER ; CRYSTALS ; FACILE ; DESIGN
WOS研究方向	Materials Science
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000490658800029
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/282729]
专题	中国科学院上海药物研究所
通讯作者	Quan, Guilan; Wu, Chuanbin
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, 501 Haike Rd, Shanghai 201203, Peoples R China 2.Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Yixian,Luo, Sulan,Niu, Boyi,et al. Ultramild One-Step Encapsulating Method as a Modular Strategy for Protecting Humidity-Susceptible Metal-Organic Frameworks Achieving Tunable Drug Release Profiles[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2019,5(10):5180-5188.
APA	Zhou, Yixian.,Luo, Sulan.,Niu, Boyi.,Wu, Biyuan.,Fu, Jintao.,...&Wu, Chuanbin.(2019).Ultramild One-Step Encapsulating Method as a Modular Strategy for Protecting Humidity-Susceptible Metal-Organic Frameworks Achieving Tunable Drug Release Profiles.ACS BIOMATERIALS SCIENCE & ENGINEERING,5(10),5180-5188.
MLA	Zhou, Yixian,et al."Ultramild One-Step Encapsulating Method as a Modular Strategy for Protecting Humidity-Susceptible Metal-Organic Frameworks Achieving Tunable Drug Release Profiles".ACS BIOMATERIALS SCIENCE & ENGINEERING 5.10(2019):5180-5188.