Stewartiacids A-N, C-23 carboxylated triterpenoids from Chinese Stewartia and their inhibitory effects against ATP-citrate lyase and NF-kappa B

doi:10.1039/c9ra09542j

	Stewartiacids A-N, C-23 carboxylated triterpenoids from Chinese Stewartia and their inhibitory effects against ATP-citrate lyase and NF-kappa B
	Wan, Jiang 3,4; Zang, Yi 5; Xiao, Dao-An 1; Li, Na 3; Li, Junmin 3; Jin, Ze-Xin 3; Chen, De-Lei 2; Xiong, Juan 4; Li, Jia 5; Hu, Jin-Feng 3,4
刊名	RSC ADVANCES
	2020-01-20
卷号	10 期号:6 页码:3343-3356
DOI	10.1039/c9ra09542j
通讯作者	Xiong, Juan() ; Li, Jia() ; Hu, Jin-Feng(jfhu@fudan.edu.cn)
英文摘要	Fourteen previously undescribed naturally occurring C-23 carboxylated triterpenoids, stewartiacids A-N (1-14), were isolated and characterized from the twigs and leaves of the ornamental and medicinal plant Stewartia sinensis (Chinese Stewartia), a 'vulnerable' species endemic to China. The new structures were elucidated on the basis of spectroscopic data, single crystal X-ray diffraction, and electronic circular dichroism (ECD) analyses. Stewartiacids A (1) and B (2) are isoursenol derivatives. Stewartiacid C (3) is a 12-oxo-gamma-amyrin analogue. Both isoursenol and gamma-amyrin derivatives are quite rare in nature. Stewartiacids D (4) and E (5) are 13,27-cycloursane-type compounds. Stewartiacids K (11) and L (12) are ursane-type triterpene and phenylpropanol adducts built through a 1,4-dioxane ring, which are also seldom reported in the literature. The rest are common C-23 carboxylated ursane-type (6-10) and oleanane-type (13, 14) pentacyclic triterpenoids. Stewartiacids G (7), K (11), and L (12) showed moderate inhibitory effects against ATP-citrate lyase (ACL), with IC50 values of 12.5, 2.8, and 10.6 mu M, respectively. Stewartiacid K (11) also exhibited moderate inhibition (IC50: 16.8 mu M) of NF-kappa B.
资助项目	NSFC[21937002] ; NSFC[81773599] ; NSFC[21772025] ; National Science and Technology Major Project for New Drug Research and Development of MOST[2019ZX09735-002]
WOS关键词	NATURAL-PRODUCTS ; PHENOLIC-COMPOUNDS ; PSEUDOCAMELLIA MAXIM. ; DERIVATIVES ; CAMELLIA ; STEM ; CONSTITUENTS ; SPINASTEROL ; ACTIVATION ; CANCER
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000508849900034
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/282402]
专题	中国科学院上海药物研究所
通讯作者	Xiong, Juan; Li, Jia; Hu, Jin-Feng
作者单位	1.Yichun Univ, Coll Chem & Bioengn, Yichun 336000, Peoples R China 2.Hefei Normal Univ, Sch Life Sci, Hefei 230601, Peoples R China 3.Taizhou Univ, Zhejiang Prov Key Lab Plant Ecol & Conservat, Sch Adv Study, Inst Nat Med & Hlth Prod, Taizhou 318000, Zhejiang, Peoples R China 4.Fudan Univ, Sch Pharm, 826 Zhangheng Rd, Shanghai 201203, Peoples R China 5.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Wan, Jiang,Zang, Yi,Xiao, Dao-An,et al. Stewartiacids A-N, C-23 carboxylated triterpenoids from Chinese Stewartia and their inhibitory effects against ATP-citrate lyase and NF-kappa B[J]. RSC ADVANCES,2020,10(6):3343-3356.
APA	Wan, Jiang.,Zang, Yi.,Xiao, Dao-An.,Li, Na.,Li, Junmin.,...&Hu, Jin-Feng.(2020).Stewartiacids A-N, C-23 carboxylated triterpenoids from Chinese Stewartia and their inhibitory effects against ATP-citrate lyase and NF-kappa B.RSC ADVANCES,10(6),3343-3356.
MLA	Wan, Jiang,et al."Stewartiacids A-N, C-23 carboxylated triterpenoids from Chinese Stewartia and their inhibitory effects against ATP-citrate lyase and NF-kappa B".RSC ADVANCES 10.6(2020):3343-3356.