Phytochemical and biological studies on rare and endangered plants endemic to China. Part XV. Structurally diverse diterpenoids and sesquiterpenoids from the vulnerable conifer Pseudotsuga sinensis

doi:10.1016/j.phytochem.2019.112184

	Phytochemical and biological studies on rare and endangered plants endemic to China. Part XV. Structurally diverse diterpenoids and sesquiterpenoids from the vulnerable conifer Pseudotsuga sinensis
	Huang, Ting 3; Ying, Sheng-Hui 3; Li, Jing-Ya 2; Chen, Hao-Wei 3; Zang, Yi 2; Wang, Wen-Xuan 1; Li, Jia 2; Xiong, Juan 3; Hu, Jin-Feng 3
刊名	PHYTOCHEMISTRY
	2020
卷号	169 页码:14
关键词	Pseudotsuga sinensis dode Pinaceae Rare and endangered plants (REPs) Degraded diterpenoids Pseudosinins ATP-Citrate lyase (ACL)
ISSN号	0031-9422
DOI	10.1016/j.phytochem.2019.112184
通讯作者	Xiong, Juan(jxiong@fudan.edu.cn) ; Hu, Jin-Feng(jfhu@fudan.edu.cn)
英文摘要	An extensive phytochemical investigation on the chemical constituents from the needles and twigs of the vulnerable conifer Pseudotsuga sinensis yielded 19 diterpenoids and 21 sesquiterpenoids with various carbocyclic skeletons. Among them, 13 (named pseudosinins A-M, resp.) were undescribed compounds. Their structures with absolute configurations were characterized by a combination of spectroscopic methods, calculated and experimental electronic circular dichroism (ECD) data, quantum chemical calculations of the chemical shifts, and single crystal X-ray diffraction analyses. In particular, an array of labdane-derived norditerpenoids with C-19-, C-18-, and C-16-skeletons, and related drimane-type sesquitepenoids with C-15- and C-13-skeletons were found in the title plant. The possible biogenetic relationships of these degraded terpenoids were briefly discussed. Among the isolates, pseudosinin D, cis-communic acid, and 4 beta,15-dihydroxy-19-norabieta-8,11,13-trien-7-one showed moderate inhibitory activities against the enzyme ATP-citrate lyase (ACL), a potential drug target for the treatment of hyperlipidemia and hypercholesterolemia.
资助项目	NSFC[81773599] ; NSFC[21937002] ; NSFC[21772025] ; MOST[2019ZX09735002-005]
WOS关键词	ATP-CITRATE LYASE ; NF-KAPPA-B ; OPLOPANAX JAPONICUS NAKAI ; ABSOLUTE-CONFIGURATION ; PINUS-DABESHANENSIS ; NATURAL-PRODUCTS ; STEM BARK ; CONSTITUENTS ; DERIVATIVES ; TERPENOIDS
WOS研究方向	Biochemistry & Molecular Biology ; Plant Sciences
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000502890200017
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/282224]
专题	中国科学院上海药物研究所
通讯作者	Xiong, Juan; Hu, Jin-Feng
作者单位	1.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Fudan Univ, Sch Pharm, Dept Nat Prod Chem, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Huang, Ting,Ying, Sheng-Hui,Li, Jing-Ya,et al. Phytochemical and biological studies on rare and endangered plants endemic to China. Part XV. Structurally diverse diterpenoids and sesquiterpenoids from the vulnerable conifer Pseudotsuga sinensis[J]. PHYTOCHEMISTRY,2020,169:14.
APA	Huang, Ting.,Ying, Sheng-Hui.,Li, Jing-Ya.,Chen, Hao-Wei.,Zang, Yi.,...&Hu, Jin-Feng.(2020).Phytochemical and biological studies on rare and endangered plants endemic to China. Part XV. Structurally diverse diterpenoids and sesquiterpenoids from the vulnerable conifer Pseudotsuga sinensis.PHYTOCHEMISTRY,169,14.
MLA	Huang, Ting,et al."Phytochemical and biological studies on rare and endangered plants endemic to China. Part XV. Structurally diverse diterpenoids and sesquiterpenoids from the vulnerable conifer Pseudotsuga sinensis".PHYTOCHEMISTRY 169(2020):14.