Smart Tumor Microenvironment-Responsive Nanotheranostic Agent for Effective Cancer Therapy

doi:10.1002/adfm.202000486

	Smart Tumor Microenvironment-Responsive Nanotheranostic Agent for Effective Cancer Therapy
	Guo, Shi-yan 1,2,3; Sun, Di 1,2; Ni, Da-long 4; Yu, Miao-rong 3; Qian, Kun 3; Zhang, Wei 3; Yang, Yi-wei 3; Song, Sha 3; Li, Yang 1,2; Xi, Zi-yue 3
刊名	ADVANCED FUNCTIONAL MATERIALS
	2020-02-28
页码	11
关键词	hypoxia relief mesoporous calcium silicate sequential functions sustained drug release synergetic effects
ISSN号	1616-301X
DOI	10.1002/adfm.202000486
通讯作者	Chen, Kai-xian(kxchen@simm.ac.cn) ; Gan, Yong(ygan@simm.ac.cn) ; Wang, Zheng-tao(ztwang@shutcm.edu.cn)
英文摘要	The tumor microenvironment (TME), which includes acidic and hypoxic conditions, severely impedes the therapeutic efficacy of antitumor agents. Herein, MnO2-loaded, bovine serum albumin, and PEG co-modified mesoporous CaSiO3 nanoparticles (CaM-PB NPs) are developed as a nanoplatform with sequential theranostic functions for the engineering of TME. The MnO2 NPs generate O-2 in situ by reacting with endogenous H2O2, relieving the hypoxic state of the TME that further modulates the cancer cell cycle status to S phase, which improves the potency of co-loaded S phase-sensitive chemotherapeutic drugs. After the hypoxia relief, CaM-PB can sustainably release drugs due to the enlarged pores of mesoporous CaSiO3 in the acidic TME, preventing the drug pre-leakage into the blood circulation and insufficient drug accumulation at tumor sites. Moreover, the Mn2+ released from the MnO2 NPs at tumor sites can potentially serve as a diagnostic agent, enabling the identification of tumor regions by T-1-weighted magnetic resonance imaging during therapy. In vivo pharmacodynamics results demonstrate that these synergetic effects caused by CaM-PB NPs significantly contribute to the inhibition of tumor progression. Therefore, the CaM-PB NPs with sequential theranostic functions are a promising system for effective cancer therapy.
资助项目	National Natural Science Foundation of China[81773651] ; National Natural Science Foundation of China[81573378] ; National Natural Science Foundation of China[81803445] ; National Natural Science Foundation of China[81920108033] ; National Natural Science Foundation of China[81703010] ; National Natural Science Foundation of China[81872428] ; Shanghai Scientific and Technology Innovation Plan ; Shanghai Science and Technology Committee[18430721600] ; China Postdoctoral Science Foundation[2016M600342] ; New Star Program, Shanghai Institute of Materia Medica, CAS ; CAS Key Technology Talent Program
WOS关键词	BOVINE SERUM-ALBUMIN ; DRUG-DELIVERY ; CELLULAR UPTAKE ; MAGNETIC NANOPARTICLES ; CIRCULATION TIME ; CALCIUM SILICATE ; HYPOXIA ; MRI ; 10-HYDROXYCAMPTOTHECIN ; ANGIOGENESIS
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000516838600001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/281507]
专题	中国科学院上海药物研究所
通讯作者	Chen, Kai-xian; Gan, Yong; Wang, Zheng-tao
作者单位	1.Shanghai Univ Tradit Chinese Med, Inst Chinese Mat Med, MOE Key Lab Standardizat Chinese Med, 1200 Cailun Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China 2.Shanghai Univ Tradit Chinese Med, Inst Chinese Mat Med, Shanghai Key Lab Compound Chinese Med, 1200 Cailun Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China 4.Univ Wisconsin, Dept Radiol, Madison, WI 53705 USA
推荐引用方式 GB/T 7714	Guo, Shi-yan,Sun, Di,Ni, Da-long,et al. Smart Tumor Microenvironment-Responsive Nanotheranostic Agent for Effective Cancer Therapy[J]. ADVANCED FUNCTIONAL MATERIALS,2020:11.
APA	Guo, Shi-yan.,Sun, Di.,Ni, Da-long.,Yu, Miao-rong.,Qian, Kun.,...&Wang, Zheng-tao.(2020).Smart Tumor Microenvironment-Responsive Nanotheranostic Agent for Effective Cancer Therapy.ADVANCED FUNCTIONAL MATERIALS,11.
MLA	Guo, Shi-yan,et al."Smart Tumor Microenvironment-Responsive Nanotheranostic Agent for Effective Cancer Therapy".ADVANCED FUNCTIONAL MATERIALS (2020):11.