Diffuse large B-cell lymphoma with low F-18-fluorodeoxyglucose avidity features silent B-cell receptor signaling

doi:10.1080/10428194.2020.1713317

	Diffuse large B-cell lymphoma with low F-18-fluorodeoxyglucose avidity features silent B-cell receptor signaling
	Sheng, Dong 2,3; Li, Ting 2,3; Wang, Wei-Ge 2,3; Li, Meng-Jiao 1,3; Jiang, Kai-Long 4; Gao, An-Hui 4; Li, Jia 4; Zhou, Xiao-Yan 2,3; Li, Xiao-Qiu 2,3
刊名	LEUKEMIA & LYMPHOMA
	2020-02-20
页码	8
关键词	Diffuse large B-cell lymphoma PET CT B-cell receptor signaling pSYK GLUT1 HK2
ISSN号	1042-8194
DOI	10.1080/10428194.2020.1713317
通讯作者	Li, Xiao-Qiu(leexiaoqiu@hotmail.com)
英文摘要	Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of aggressive lymphomas exhibiting increased glucose uptake. However, some DLBCLs featuring relatively low F-18-fluorodeoxyglucose (F-18-FDG) uptake denoted by the maximum standardized uptake value (SUVmax) on PET/CT have been identified. The biologic correlates of such a heterogeneity have remained largely unknown. Herein, we immunohistochemically detected and found low FDG-avid DLBCL cases featuring lower expression of some key molecules involved in B-cell receptor (BCR) signaling (pSYK) and glucose metabolism (GLUT1 and HK2). Besides, BCR-deficient DLBCL xenografts were found displaying lower SUVmax and expressions of pSYK, GLUT1, and HK2. Further immunoblotting demonstrated expressions of GLUT1 and HK2 in BCR-dependent DLBCLs could be down-regulated by a chemical SYK inhibition, whereas the inhibitory effects were not observed in BCR-deficient tumors. These findings suggest low FDG-avid DLBCLs display a silent BCR signaling and PET/CT might be utilized to tailor the BCR signaling-inhibitory treatment.
资助项目	Guide Project of Science and Technology Commission of Shanghai Municipality[134119a5000] ; Natural Science Foundation of Shanghai Municipality[11ZR1407100]
WOS关键词	TARGETING BTK ; IBRUTINIB ; RITUXIMAB ; PET/CT ; SYK ; SURVIVAL ; THERAPY ; CHOP
WOS研究方向	Oncology ; Hematology
语种	英语
出版者	TAYLOR & FRANCIS LTD
WOS记录号	WOS:000515232600001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/281333]
专题	中国科学院上海药物研究所
通讯作者	Li, Xiao-Qiu
作者单位	1.Fudan Univ, Dept Gynecol Oncol, Shanghai Canc Ctr, Shanghai, Peoples R China 2.Fudan Univ, Dept Pathol, Shanghai Canc Ctr, 270 Dong An Rd, Shanghai 200032, Peoples R China 3.Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Sheng, Dong,Li, Ting,Wang, Wei-Ge,et al. Diffuse large B-cell lymphoma with low F-18-fluorodeoxyglucose avidity features silent B-cell receptor signaling[J]. LEUKEMIA & LYMPHOMA,2020:8.
APA	Sheng, Dong.,Li, Ting.,Wang, Wei-Ge.,Li, Meng-Jiao.,Jiang, Kai-Long.,...&Li, Xiao-Qiu.(2020).Diffuse large B-cell lymphoma with low F-18-fluorodeoxyglucose avidity features silent B-cell receptor signaling.LEUKEMIA & LYMPHOMA,8.
MLA	Sheng, Dong,et al."Diffuse large B-cell lymphoma with low F-18-fluorodeoxyglucose avidity features silent B-cell receptor signaling".LEUKEMIA & LYMPHOMA (2020):8.