Uncommon nornardosinane, seconeolemnane and related sesquiterpenoids from Xisha soft coral Litophyton nigrum

doi:10.1016/j.bioorg.2020.103636

	Uncommon nornardosinane, seconeolemnane and related sesquiterpenoids from Xisha soft coral Litophyton nigrum
	Yang, Fan 1,2,3,4; Li, Song-Wei 2; Zhang, Jun 4; Liang, Lin-Fu 2,5; Lu, Yan-Hua 1,3; Guo, Yue-Wei 2
刊名	BIOORGANIC CHEMISTRY
	2020-03-01
卷号	96 页码:8
关键词	Litophyton nigrum Nornardosinane Seconeolemnane Cytotoxicity Inhibitory activity
ISSN号	0045-2068
DOI	10.1016/j.bioorg.2020.103636
通讯作者	Liang, Lin-Fu(lianglinfu@aliyun.com) ; Lu, Yan-Hua(luyanhua@ecust.edu.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn)
英文摘要	Three new nardosinane-type sesquiterpenoids linardosinenes A-C (1-3) and four new neolemnane-type sesquiterpenoids lineolemnenes A-D (4-7), together with the related known compound 4-acetoxy-2,8-neolemnadien-5-one (8), were isolated from the Xisha soft coral Litophyton nigrum. The structures of these new compounds were elucidated by comprehensive analyses of spectroscopic data, in association with modified Mosher's method and ECD calculations for configurational assignments and the absolute configuration of 8 was determined by X-ray diffraction analysis for the first time. Structurally uncommon nornardosinane and seconeolemnane skeletons for compounds 1 and 7, respectively, are rare carbon frameworks in naturally occurring sesquiterpenoids. The absolute configurations of 1, 7, and 8 were determined by modified Mosher's method, TDDFT ECD approach, and X-ray diffraction analysis, respectively. This is the first chemical study of L. nigrum and the first report of nornardosinane, seconeolemnane and related sesquiterpenoids from the genus Litophyton. The isolates 1-7 were evaluated for their cytotoxicity against THP-1, SNU-398, HT-29, Capan-1 and A549 cell lines and inhibitory activities against PTP1B, BRD4, HDAC1 and HDAC6 protein kinases. The results indicated that compounds 2-5 inhibited proliferation of human cancer cells. However, none of them were potent inhibitors of protein kinases.
资助项目	National Natural Science Foundation of China, China[81991521] ; National Natural Science Foundation of China, China[81520108028] ; National Natural Science Foundation of China, China[21672230] ; National Natural Science Foundation of China, China[41876194] ; National Natural Science Foundation of China, China[41876189] ; National Natural Science Foundation of China, China[81603022] ; National Key Research and Development Program of China, China[2018YFC0310903] ; National Key Research and Development Program of China, China[2018YFC1706200] ; Drug Innovation Major Project, China[2018ZX09711-001-001-009] ; SKLDR/SIMM, China Projects[SIMM1903ZZ-04]
WOS关键词	NORSESQUITERPENOIDS ; GROWTH
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号	WOS:000516796900076
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/280963]
专题	中国科学院上海药物研究所
通讯作者	Liang, Lin-Fu; Lu, Yan-Hua; Guo, Yue-Wei
作者单位	1.East China Univ Sci & Technol, State Key Lab Bioreactor Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China 3.Shanghai Collaborat Innovat Ctr Biomfg Technol, 130 Meilong Rd, Shanghai 200237, Peoples R China 4.Shanghai Normal Univ, Coll Life & Environm Sci, Biol Dept, 100 Guilin Rd, Shanghai 200234, Peoples R China 5.Cent South Univ Forestry & Technol, Coll Mat Sci & Engn, 498 South Shaoshan Rd, Changsha 410004, Peoples R China
推荐引用方式 GB/T 7714	Yang, Fan,Li, Song-Wei,Zhang, Jun,et al. Uncommon nornardosinane, seconeolemnane and related sesquiterpenoids from Xisha soft coral Litophyton nigrum[J]. BIOORGANIC CHEMISTRY,2020,96:8.
APA	Yang, Fan,Li, Song-Wei,Zhang, Jun,Liang, Lin-Fu,Lu, Yan-Hua,&Guo, Yue-Wei.(2020).Uncommon nornardosinane, seconeolemnane and related sesquiterpenoids from Xisha soft coral Litophyton nigrum.BIOORGANIC CHEMISTRY,96,8.
MLA	Yang, Fan,et al."Uncommon nornardosinane, seconeolemnane and related sesquiterpenoids from Xisha soft coral Litophyton nigrum".BIOORGANIC CHEMISTRY 96(2020):8.