Activation of a gamma-cyclodextrin-based metal-organic framework using supercritical carbon dioxide for high-efficient delivery of honokiol

doi:10.1016/j.carbpol.2020.115935

	Activation of a gamma-cyclodextrin-based metal-organic framework using supercritical carbon dioxide for high-efficient delivery of honokiol
	He, Yuanzhi 3; Hou, Xuefeng 3; Guo, Jingwen 3; He, Zehui 3; Guo, Teng 3; Liu, Ying 3; Zhang, Yongtai 3; Zhang, Jiwen 1,2; Feng, Nianping 3
刊名	CARBOHYDRATE POLYMERS
	2020-05-01
卷号	235 页码:10
关键词	gamma-cyclodextrin metal-organic framework Activation Honokiol Supercritical carbon dioxide Bioavailability
ISSN号	0144-8617
DOI	10.1016/j.carbpol.2020.115935
通讯作者	Feng, Nianping(npfeng@hotmail.com)
英文摘要	A facile method for the activation of gamma-cyclodextrin metal-organic framework (CD-MOF) without channel blockage and framework collapse was first developed using supercritical carbon dioxide (scCO(2)), which enabled higher surface area and larger pore volume. The scCO(2)-assisted impregnation method was also applied to introduce the insoluble drug, honokiol (HNK), into the pores of CD-MOF with higher cargo loading compared to the conventional liquid phase incorporation in ethanol. Notably, the resulting HNK-loaded CD-MOF (HNK@CD-MOF) had improved apparent solubility and enhanced dissolution rate. The intestinal cellular uptake and transport experiments demonstrated that CD-MOF could enhance cellular uptake and increase drug transport across the intestinal epithelial cells compared to the cyclodextrin inclusion complex. Moreover, the in vivo pharmacokinetic studies further confirmed that CD-MOF could significantly improve the oral absorption and bioavailability of HNK. Overall, the scCO(2) activation and scCO(2)-assisted impregnation approaches were demonstrated as promising strategies to maximize the potential capability of CD-MOF.
资助项目	National Natural Science Foundation of China[81573619]
WOS关键词	INCREASED ORAL BIOAVAILABILITY ; CD-MOF ; INCLUSION COMPLEX ; DRUG-DELIVERY ; NANOPARTICLES ; ENCAPSULATION ; PHARMACOKINETICS ; STABILITY ; ENHANCEMENT ; SOLUBILITY
WOS研究方向	Chemistry ; Polymer Science
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000519044900009
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/280840]
专题	中国科学院上海药物研究所
通讯作者	Feng, Nianping
作者单位	1.Natl Inst Food & Drug Control, NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipi, 2 Tiantan Xili, Beijing 100050, Peoples R China 2.Chinese Acad Sci, Ctr Drug Delivery Syst, Shanghai Inst Mat Med, Shanghai 201210, Peoples R China 3.Shanghai Univ Tradit Chinese Med, Sch Pharm, Dept Pharmaceut Sci, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	He, Yuanzhi,Hou, Xuefeng,Guo, Jingwen,et al. Activation of a gamma-cyclodextrin-based metal-organic framework using supercritical carbon dioxide for high-efficient delivery of honokiol[J]. CARBOHYDRATE POLYMERS,2020,235:10.
APA	He, Yuanzhi.,Hou, Xuefeng.,Guo, Jingwen.,He, Zehui.,Guo, Teng.,...&Feng, Nianping.(2020).Activation of a gamma-cyclodextrin-based metal-organic framework using supercritical carbon dioxide for high-efficient delivery of honokiol.CARBOHYDRATE POLYMERS,235,10.
MLA	He, Yuanzhi,et al."Activation of a gamma-cyclodextrin-based metal-organic framework using supercritical carbon dioxide for high-efficient delivery of honokiol".CARBOHYDRATE POLYMERS 235(2020):10.