dynamicmodificationsofbiomacromoleculesmechanismandchemicalinterventions

doi:10.1007/s11427-019-9823-1

	dynamicmodificationsofbiomacromoleculesmechanismandchemicalinterventions
	Wang Chu 1; Zou Peng 1; Yang Caiguang 2; Liu Lei 3; Cheng Liang 4; He Xiaopeng 5; Zhang Liang 6; Zhang Yan 7; Jiang Hualiang 2; Chen Peng R 1
刊名	sciencechinalifesciences
	2019
卷号	62 期号:11 页码:1459
关键词	POSTTRANSLATIONAL MODIFICATIONS PROTEIN LIPIDATION DNA METHYLATION TARGET IDENTIFICATION GLYCOSYLATION CHEMISTRY HEALTH DYRK2 P53 chemical biology biomacromolecule dynamic modification modification analysis chemical intervention
ISSN号	1674-7305
DOI	10.1007/s11427-019-9823-1
英文摘要	Biological macromolecules (proteins, nucleic acids, polysaccharides, etc.) are the building blocks of life, which constantly undergo chemical modifications that are often reversible and spatial-temporally regulated. These dynamic properties of chemical modifications play fundamental roles in physiological processes as well as pathological changes of living systems. The Major Research Project (MRP) funded by the National Natural Science Foundation of China (NSFC)-"Dynamic modifications of biomacromolecules: mechanism and chemical interventions" aims to integrate cross-disciplinary approaches at the interface of chemistry, life sciences, medicine, mathematics, material science and information science with the following goals: (i) developing specific labeling techniques and detection methods for dynamic chemical modifications of biomacromolecules, (ii) analyzing the molecular mechanisms and functional relationships of dynamic chemical modifications of biomacromolecules, and (iii) exploring biomacromolecules and small molecule probes as potential drug targets and lead compounds.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/280769]
专题	中国科学院上海药物研究所
作者单位	1.北京大学 2.中国科学院上海药物研究所 3.清华大学 4.中国科学院化学研究所 5.华东理工大学 6.上海交通大学医学院 7.National Natural Science Foundation of China
推荐引用方式 GB/T 7714	Wang Chu,Zou Peng,Yang Caiguang,et al. dynamicmodificationsofbiomacromoleculesmechanismandchemicalinterventions[J]. sciencechinalifesciences,2019,62(11):1459.
APA	Wang Chu.,Zou Peng.,Yang Caiguang.,Liu Lei.,Cheng Liang.,...&Chen Peng R.(2019).dynamicmodificationsofbiomacromoleculesmechanismandchemicalinterventions.sciencechinalifesciences,62(11),1459.
MLA	Wang Chu,et al."dynamicmodificationsofbiomacromoleculesmechanismandchemicalinterventions".sciencechinalifesciences 62.11(2019):1459.