Three new bisflavonols from the seeds of Hovenia dulcis Thunb. and their anti-RSV activities

doi:10.1016/j.fitote.2020.104587

	Three new bisflavonols from the seeds of Hovenia dulcis Thunb. and their anti-RSV activities
	Xu, Fangfang 3,4; Gao, Meihua 2; Li, Hua 2; Han, Xiaodong 4; Zhang, Xiaoqi 5; Li, Yaolan 5; Guo, De-an 1,4; Liu, Bo 3,4
刊名	FITOTERAPIA
	2020-06-01
卷号	143 页码:6
关键词	Hovenia dulcis Thunb. Bisflavonol Flavonoids Anti-RSV activity
ISSN号	0367-326X
DOI	10.1016/j.fitote.2020.104587
通讯作者	Li, Hua(lihua@gdidc.org.cn) ; Guo, De-an(daguo@simm.ac.cn) ; Liu, Bo(doctliu@263.net)
英文摘要	Three novel bisflavonol derivatives, Hovenianins A-C, along with 12 known flavonoids were isolated and identified from the seeds of Hovenia dulcis Thunb. Their structures were established on the basis of spectroscopic methods (MS, UV, IR, 1D and 2D NMR) and electronic circular dichroism experiments. Hovenianin A (1) was the first dimer of flavonol linked dihydroflavonol via the B rings at C-2' and C-2'''positions to be found in nature. While Hovenianins BC (2-3) were a pair of diastereoisomeric bis-dihydroflavonols firstly reported in the Hovenia genus. The in vitro antiviral activity against respiratory syncytium virus (RSV) were evaluated by cytopathic effect (CPE) reduction assay. As a result, compounds 4, 5, and 10 displayed better antiviral effect against RSV A2 strains.
资助项目	National Natural Science Foundation of China[81703379] ; National Natural Science Foundation of China[U1801287] ; Science and Technology Planning Project of Guangdong Province[2017B030314166] ; Science and Technology Planning Project of Guangdong Province[2018B020207008] ; Special Funds for Inheriting and Developing the Traditional Chinese Medicine from TCM Bureau of Guangdong Province[20181121] ; Special Funds for Inheriting and Developing the Traditional Chinese Medicine from TCM Bureau of Guangdong Province[20191137] ; Special Funds for Inheriting and Developing the Traditional Chinese Medicine from TCM Bureau of Guangdong Province[20191142] ; Specific Research Fund for TCM Science and Technology of Guangdong Provincial Hospital of Chinese Medicine[YN2016QJ05] ; Specific Research Fund for TCM Science and Technology of Guangdong Provincial Hospital of Chinese Medicine[YN2015MS03] ; Key Project of High-level University Construction of Guangzhou University of Chinese Medicine[XK2018019]
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000532686800035
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/280367]
专题	中国科学院上海药物研究所
通讯作者	Li, Hua; Guo, De-an; Liu, Bo
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China 2.Guangdong Inst Drug Control, Guangzhou 510663, Peoples R China 3.Guangzhou Key Lab Chiral Res Act Components Tradi, Guangzhou 510006, Peoples R China 4.Guangzhou Univ Chinese Med, Second Clin Medicial Coll, Guangdong Prov Key Lab Clin Res Tradit Chinese Me, Guangzhou 510006, Peoples R China 5.Jinan Univ, Coll Pharm, Guangdong Prov Engn Res Ctr Modernizat TCM, Guangzhou 510632, Peoples R China
推荐引用方式 GB/T 7714	Xu, Fangfang,Gao, Meihua,Li, Hua,et al. Three new bisflavonols from the seeds of Hovenia dulcis Thunb. and their anti-RSV activities[J]. FITOTERAPIA,2020,143:6.
APA	Xu, Fangfang.,Gao, Meihua.,Li, Hua.,Han, Xiaodong.,Zhang, Xiaoqi.,...&Liu, Bo.(2020).Three new bisflavonols from the seeds of Hovenia dulcis Thunb. and their anti-RSV activities.FITOTERAPIA,143,6.
MLA	Xu, Fangfang,et al."Three new bisflavonols from the seeds of Hovenia dulcis Thunb. and their anti-RSV activities".FITOTERAPIA 143(2020):6.