Patchouli Alcohol: a Natural Sesquiterpene Against Both Inflammation and Intestinal Barrier Damage of Ulcerative Colitis

doi:10.1007/s10753-020-01219-8

	Patchouli Alcohol: a Natural Sesquiterpene Against Both Inflammation and Intestinal Barrier Damage of Ulcerative Colitis
	Wu, Zhuona 2,3; Zeng, Hairong 1; Zhang, Lili 2; Pu, Yiqiong 3; Li, Suyun 4; Yuan, Yi 1; Zhang, Tong 2,3; Wang, Bing 2,5,6
刊名	INFLAMMATION
	2020-05-09
页码	13
关键词	patchouli alcohol ulcerative colitis intestinal integrity anti-inflammatory
ISSN号	0360-3997
DOI	10.1007/s10753-020-01219-8
通讯作者	Yuan, Yi(yuanyi0625@163.com) ; Zhang, Tong(zhangtdmj@hotmail.com) ; Wang, Bing(bwang@simm.ac.cn)
英文摘要	Ulcerative colitis (UC) is a chronic and relapsing inflammatory disorder of the gastrointestinal tract, characterized by diarrhea, hematochezia, abdominal distension, and abdominal pain. The perpetuation of inflammation and the impairment of the intestinal barrier are part of the main courses of UC, responsible for the deteriorating inflammatory condition. Patchouli alcohol (PA), extracted from Pogostemon cablin Benth., is employed to treat both inflammation and intestinal barrier damage. Its curative effect on UC was testified firstly by TNBS-induced UC, a chemically induced colitis, and further tested by DSS-induced UC, an acute attack stage of UC in which the clinical course of human UC occurs frequently. PA reduced the levels of TNF-alpha, IFN-gamma, IL-1 beta, IL-6, and IL-17 in serum and decreased the mRNA expression of pro-inflammatory cytokines (e.g., iNOS, COX-2, TNF-alpha, IL-1 beta, and IL-6). Concurrently, PA upregulated the expression of tight junction protein (e.g., ZO-1, ZO-2, claudin-1, and occludin) and the mRNA of mucin-1 and mucin-2 in both animal models. Further, PA ameliorated both histological damage and clinical parameters. Thus, PA could credibly reduce the expression of pro-inflammatory cytokines, protect the integrity of intestinal epithelial barrier, and repair the macroscopic colon lesions in both colitis models.
资助项目	Program of Shanghai Committee of Science and Technology of China[17401902300] ; Program of Shanghai Academic/Technology Research Leader of China[18XD1403700]
WOS关键词	ANTIINFLAMMATORY ACTIVITY ; POGOSTEMONIS HERBA ; COLORECTAL-CANCER ; BOWEL-DISEASE ; RAW264.7 ; STRESS ; RISK ; MICE ; OIL
WOS研究方向	Cell Biology ; Immunology
语种	英语
出版者	SPRINGER/PLENUM PUBLISHERS
WOS记录号	WOS:000531197300001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/280281]
专题	中国科学院上海药物研究所
通讯作者	Yuan, Yi; Zhang, Tong; Wang, Bing
作者单位	1.Shanghai Univ Tradit Chinese Med, Putuo Hosp, Dept Pharm, 164 Lanxi Rd, Shanghai 200062, Peoples R China 2.Shanghai Univ Tradit Chinese Med, Sch Pharm, 1200 Cailun Rd, Shanghai 201203, Peoples R China 3.Shanghai Univ Tradit Chinese Med, Expt Ctr Teaching & Learning, 1200 Cailun Rd, Shanghai 201203, Peoples R China 4.Shanghai Univ Tradit Chinese Med, Sch Basic Med Sci, 1200 Cailun Rd, Shanghai 201203, Peoples R China 5.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China 6.Chinese Acad Sci, Ctr Pharmaceut Res, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Wu, Zhuona,Zeng, Hairong,Zhang, Lili,et al. Patchouli Alcohol: a Natural Sesquiterpene Against Both Inflammation and Intestinal Barrier Damage of Ulcerative Colitis[J]. INFLAMMATION,2020:13.
APA	Wu, Zhuona.,Zeng, Hairong.,Zhang, Lili.,Pu, Yiqiong.,Li, Suyun.,...&Wang, Bing.(2020).Patchouli Alcohol: a Natural Sesquiterpene Against Both Inflammation and Intestinal Barrier Damage of Ulcerative Colitis.INFLAMMATION,13.
MLA	Wu, Zhuona,et al."Patchouli Alcohol: a Natural Sesquiterpene Against Both Inflammation and Intestinal Barrier Damage of Ulcerative Colitis".INFLAMMATION (2020):13.