Analysis of Four Types of Leukemia Using Gene Ontology Term and Kyoto Encyclopedia of Genes and Genomes Pathway Enrichment Scores

doi:10.2174/1386207322666181231151900

	Analysis of Four Types of Leukemia Using Gene Ontology Term and Kyoto Encyclopedia of Genes and Genomes Pathway Enrichment Scores
	Lu, Jing 2; Zhang, YuHang 3; Wang, ShaoPeng 1; Bi, Yi 2; Huang, Tao 3; Luo, Xiaomin 4; Cai, Yu-Dong 1
刊名	COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
	2020
卷号	23 期号:4 页码:295-303
关键词	Leukemia protein-drug interactions GO term KEGG pathway enrichment score mRMR
ISSN号	1386-2073
DOI	10.2174/1386207322666181231151900
通讯作者	Lu, Jing(lujing_ytu@126.com) ; Luo, Xiaomin(xmluo@simm.ac.cn) ; Cai, Yu-Dong(cai_yud@126.com)
英文摘要	Aim and Objective: Leukemia is the second common blood cancer after lymphoma, and its incidence rate has an increasing trend in recent years. Leukemia can be classified into four types: acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL), and chronic myelogenous leukemia (CML). More than forty drugs are applicable to different types of leukemia based on the discrepant pathogenesis. Therefore, the identification of specific drug-targeted biological processes and pathways is helpful to determinate the underlying pathogenesis among such four types of leukemia. Methods: In this study, the gene ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways that were highly related to drugs for leukemia were investigated for the first time. The enrichment scores for associated GO terms and KEGG pathways were calculated to evaluate the drugs and leukemia. The feature selection method, minimum redundancy maximum relevance (mRMR), was used to analyze and identify important GO terms and KEGG pathways. Results: Twenty Go terms and two KEGG pathways with high scores have all been confirmed to effectively distinguish four types of leukemia. Conclusion: This analysis may provide a useful tool for the discrepant pathogenesis and drug design of different types of leukemia.
资助项目	National Natural Science Foundation of China[81603024] ; Project of Shandong Province Higher Educational Science and Technology Program[J16LM02]
WOS关键词	ACUTE LYMPHOBLASTIC-LEUKEMIA ; CHRONIC LYMPHOCYTIC-LEUKEMIA ; BRUTON TYROSINE KINASE ; ACUTE MYELOID-LEUKEMIA ; WNT-SIGNALING PATHWAY ; MYELOMONOCYTIC LEUKEMIA ; IMATINIB MESYLATE ; SONIC HEDGEHOG ; CELLS ; KEGG
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy
语种	英语
出版者	BENTHAM SCIENCE PUBL LTD
WOS记录号	WOS:000535714900004
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/280140]
专题	中国科学院上海药物研究所
通讯作者	Lu, Jing; Luo, Xiaomin; Cai, Yu-Dong
作者单位	1.Shanghai Univ, Sch Life Sci, 99 Shangda Rd, Shanghai 200444, Peoples R China 2.Yantai Univ, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Key Lab Mol Pharmacol & Drug Evaluat, Sch Pharm,Minist Educ, 32 Qingquan Rd, Yantai 264005, Peoples R China 3.Chinese Acad Sci, Inst Hlth Sci, Shanghai Inst Biol Sci, 30 Yueyang Rd, Shanghai 00031, Peoples R China 4.Chinese Acad Sci, Drug Discovery & Design Ctr, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Lu, Jing,Zhang, YuHang,Wang, ShaoPeng,et al. Analysis of Four Types of Leukemia Using Gene Ontology Term and Kyoto Encyclopedia of Genes and Genomes Pathway Enrichment Scores[J]. COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING,2020,23(4):295-303.
APA	Lu, Jing.,Zhang, YuHang.,Wang, ShaoPeng.,Bi, Yi.,Huang, Tao.,...&Cai, Yu-Dong.(2020).Analysis of Four Types of Leukemia Using Gene Ontology Term and Kyoto Encyclopedia of Genes and Genomes Pathway Enrichment Scores.COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING,23(4),295-303.
MLA	Lu, Jing,et al."Analysis of Four Types of Leukemia Using Gene Ontology Term and Kyoto Encyclopedia of Genes and Genomes Pathway Enrichment Scores".COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING 23.4(2020):295-303.