Enhanced oral bioavailability and bioefficacy of phloretin using mixed polymeric modified self-nanoemulsions

doi:10.1002/fsn3.1637

	Enhanced oral bioavailability and bioefficacy of phloretin using mixed polymeric modified self-nanoemulsions
	Wang, Yiling 2; Li, Dongli 2; Lin, Huiqiong 1; Jiang, Sen 1; Han, Lei 1; Hou, Shuli 1; Lin, Shuying 1; Cheng, Zhefeng 1; Bian, Wangqing 1; Zhang, Xinxin 3
刊名	FOOD SCIENCE & NUTRITION
	2020-05-28
页码	14
关键词	anti-inflammatory bioavailability pharmacokinetics phloretin self-nanoemulsions solubility
ISSN号	2048-7177
DOI	10.1002/fsn3.1637
通讯作者	He, Yan(lzbzm@163.com) ; Zhang, Kun(Zhangtinghua_js@163.com)
英文摘要	Phloretin (Ph) is a natural active ingredient with wide biological properties. However, its poor water-solubility and low oral bioavailability limit the application significantly in functional food and drug. This study was to explore the mixed polymer Pluronic (R) F127 and P123 modified the different triglycerides (LCT, MCT, SCT) in self-nanoemulsions (SNEs) for enhancing the oral bioavailability and bioefficacy of Ph. The SNEs were characterized in terms of physical property study, lipolysis study, pharmacokinetic study, and anti-inflammatory effect. The water-solubility of LCT-Ph-SNE increased 3000-fold compared with Ph solution. Pharmacokinetic study of SNEs and other carriers (HP-beta-CD, PVP) results indicated that LCT-Ph-SNE was 7.9-fold more bioavailable compared with unformulated Ph. The anti-inflammatory activity of LCT-Ph-SNE in vivo represented a 6.8-fold enhancement compared with unformulated Ph. This novel SNE formulation may also be used for other poorly soluble ingredients with high loading capacity, which made a significant impact on functional food and drug.
资助项目	Department of Science and Technology of Jiangmen[2016350100170008351] ; Jiangmen Program for Innovative Research Team[2018630100180019806] ; Department of Education of Guangdong Province[2016KCXTD005] ; Department of Education of Guangdong Province[2017KSYS010]
WOS关键词	DRUG-DELIVERY SYSTEM ; ANTIOXIDANT ; FORMULATION ; INHIBITION ; DIGESTION
WOS研究方向	Food Science & Technology
语种	英语
出版者	WILEY
WOS记录号	WOS:000535881700001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/280048]
专题	中国科学院上海药物研究所
通讯作者	He, Yan; Zhang, Kun
作者单位	1.Guangdong Univ Technol, Sch Biomed & Pharmaceut Sci, Guangzhou 510006, Peoples R China 2.Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen 529020, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Wang, Yiling,Li, Dongli,Lin, Huiqiong,et al. Enhanced oral bioavailability and bioefficacy of phloretin using mixed polymeric modified self-nanoemulsions[J]. FOOD SCIENCE & NUTRITION,2020:14.
APA	Wang, Yiling.,Li, Dongli.,Lin, Huiqiong.,Jiang, Sen.,Han, Lei.,...&Zhang, Kun.(2020).Enhanced oral bioavailability and bioefficacy of phloretin using mixed polymeric modified self-nanoemulsions.FOOD SCIENCE & NUTRITION,14.
MLA	Wang, Yiling,et al."Enhanced oral bioavailability and bioefficacy of phloretin using mixed polymeric modified self-nanoemulsions".FOOD SCIENCE & NUTRITION (2020):14.