Error-corrected estimation of a diagnostic accuracy index of a biomarker against a continuous gold standard

doi:10.1002/sim.8818

	Error-corrected estimation of a diagnostic accuracy index of a biomarker against a continuous gold standard
	Wu, Mixia 2; Zhang, Xiaoyu 2; Zhang, Wei 3; Zhang, Xu 2; Liu, Aiyi 1
刊名	STATISTICS IN MEDICINE
	2020-11-27
页码	25
关键词	adaptive estimation additive errors asymptotic normality biomarkers diagnostic accuracy measurement errors reliability coefficient
ISSN号	0277-6715
DOI	10.1002/sim.8818
英文摘要	This article concerns evaluating the effectiveness of a continuous diagnostic biomarker against a continuous gold standard that is measured with error. Extending the work of Obuchowski (2005, 2016), Wu et al (2016) suggested an accuracy index and proposed an estimator for the index with error-prone standard when the reliability coefficient is known. Combining with additional measurements (without measurement errors) on the continuous gold standard collected from some subjects, this article proposes two adaptive estimators of the accuracy index when the reliability coefficient is unknown, and further establish the consistency and asymptotic normality of these estimators. Simulation studies are conducted to compare various estimators. Data from an intervention trial on glycemic control among children with type 1 diabetes are used to illustrate the proposed methods.
资助项目	Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development
WOS研究方向	Mathematical & Computational Biology ; Public, Environmental & Occupational Health ; Medical Informatics ; Research & Experimental Medicine ; Mathematics
语种	英语
出版者	WILEY
WOS记录号	WOS:000593002800001
内容类型	期刊论文
源URL	[http://ir.amss.ac.cn/handle/2S8OKBNM/52504]
专题	中国科学院数学与系统科学研究院
通讯作者	Liu, Aiyi
作者单位	1.Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Biostat & Bioinformat Branch, NIH, Bethesda, MD USA 2.Beijing Univ Technol, Coll Stat & Data Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Acad Math & Syst Sci, NCMIS, LSC, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Wu, Mixia,Zhang, Xiaoyu,Zhang, Wei,et al. Error-corrected estimation of a diagnostic accuracy index of a biomarker against a continuous gold standard[J]. STATISTICS IN MEDICINE,2020:25.
APA	Wu, Mixia,Zhang, Xiaoyu,Zhang, Wei,Zhang, Xu,&Liu, Aiyi.(2020).Error-corrected estimation of a diagnostic accuracy index of a biomarker against a continuous gold standard.STATISTICS IN MEDICINE,25.
MLA	Wu, Mixia,et al."Error-corrected estimation of a diagnostic accuracy index of a biomarker against a continuous gold standard".STATISTICS IN MEDICINE (2020):25.