Group analysis of distance matrices

doi:10.1002/gepi.22329

	Group analysis of distance matrices
	Wang, Jinjuan 1,2; Li, Jialu 4; Xiong, Wenjun 3; Li, Qizhai 1,2
刊名	GENETIC EPIDEMIOLOGY
	2020-06-21
页码	9
关键词	distance-based regression eigenvalue decomposition pseudoFtest statistic
ISSN号	0741-0395
DOI	10.1002/gepi.22329
英文摘要	Distance-based regression model has become a powerful approach to identifying phenotypic associations in many fields. It is found to be particularly useful for high-dimensional biological and genetic data with proper distance or similarity measures being available. The pseudoFstatistic used in this model accumulates information and is effective when the signals, that is the variations represented by the eigenvalues of the similarity matrix, scatter evenly along the eigenvectors of the similarity matrix. However, it might lose power for the uneven signals. To deal with this issue, we propose a group analysis on the variations of signals along the eigenvalues of the similarity matrix and take the maximum among them. The new procedure can automatically choose an optimal grouping point on some given thresholds and thus can improve the power evidence. Extensive computer simulations and applications to a prostate cancer data and an aging human brain data illustrate the effectiveness of the proposed method.
资助项目	National Natural Science Foundation of China[11722113] ; Natural Science Foundation of Beijing Municipality[Z180006]
WOS研究方向	Genetics & Heredity ; Mathematical & Computational Biology
语种	英语
出版者	WILEY
WOS记录号	WOS:000541436300001
内容类型	期刊论文
源URL	[http://ir.amss.ac.cn/handle/2S8OKBNM/51690]
专题	中国科学院数学与系统科学研究院
通讯作者	Li, Qizhai
作者单位	1.Univ Chinese Acad Sci, Beijing, Peoples R China 2.Chinese Acad Sci, Acad Math & Syst Sci, NCMIS, LSC, Beijing 100190, Peoples R China 3.Guangxi Normal Univ, Guangxi, Peoples R China 4.Beijing Inst Technol, Sch Math & Stat, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Wang, Jinjuan,Li, Jialu,Xiong, Wenjun,et al. Group analysis of distance matrices[J]. GENETIC EPIDEMIOLOGY,2020:9.
APA	Wang, Jinjuan,Li, Jialu,Xiong, Wenjun,&Li, Qizhai.(2020).Group analysis of distance matrices.GENETIC EPIDEMIOLOGY,9.
MLA	Wang, Jinjuan,et al."Group analysis of distance matrices".GENETIC EPIDEMIOLOGY (2020):9.