Combined use of Y-tube conduits with human umbilical cord stem cells for repairing nerve bifurcation defects

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	Combined use of Y-tube conduits with human umbilical cord stem cells for repairing nerve bifurcation defects
	Muheremu Aikeremujiang 1; Sun Jungang 4; Wang Xiyuan 2; Zhang Fei 3; Ao Qiang 2; Peng Jiang 5
刊名	Neural Regeneration Research
	2016
卷号	11 期号:4 页码:664-669
关键词	nerve regeneration Neurology. Diseases of the nervous system RC346-429 peripheral nerve injury nerve conduit selective nerve regeneration chemotaxis human umbilical cord blood stem cell stem cell transplantation neural regeneration
ISSN号	1673-5374
其他题名	Combined use of Y-tube conduits with human umbilical cord stem cells for repairing nerve bifurcation defects
英文摘要	Given the anatomic complexity at the bifurcation point of a nerve trunk, enforced suturing between stumps can lead to misdirection of nerve axons, thereby resulting in adverse consequences. We assumed that Y-tube conduits injected with human umbilical cord stem cells could be an effective method to solve such problems, but studies focused on the best type of Y-tube conduit remain controversial. Therefore, the present study evaluated the applicability and efficacy of various types of Y-tube conduits containing human umbilical cord stem cells for treating rat femoral nerve defects on their bifurcation points. At 12 weeks after the bridging surgery that included treatment with different types of Y-tube conduits, there were no differences in quadriceps femoris muscle weight or femoral nerve ultrastructure. However, the Y-tube conduit group with longer branches and a short trunk resulted in a better outcome according to retrograde labeling and electrophysiological analysis. It can be concluded from the study that repairing a mixed nerve defect at its bifurcation point with Y-tube conduits, in particular those with long branches and a short trunk, is effective and results in good outcomes.
资助项目	[National High Technology Research and Development Program of China ("863" Program)] ; [National Natural Science Foundation of China] ; [National Basic Research Program of China (973 program)]
语种	英语
CSCD记录号	CSCD:5690847
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/157818]
专题	金属研究所_中国科学院金属研究所
作者单位	1.清华大学 2.中国科学院金属研究所 3.Xinjiang Med University, Affiliated Hosp 5, Dept Orthoped, Urumqi, Xinjiang Uygur, Peoples R China 4.Peoples Hosp Xinjiang Uygur Autonomous Reg, Department Orthoped, Urumqi, Xinjiang Uygur, Peoples R China 5.Gen Hosp PLA, Institute Orthopaed, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Muheremu Aikeremujiang,Sun Jungang,Wang Xiyuan,et al. Combined use of Y-tube conduits with human umbilical cord stem cells for repairing nerve bifurcation defects[J]. Neural Regeneration Research,2016,11(4):664-669.
APA	Muheremu Aikeremujiang,Sun Jungang,Wang Xiyuan,Zhang Fei,Ao Qiang,&Peng Jiang.(2016).Combined use of Y-tube conduits with human umbilical cord stem cells for repairing nerve bifurcation defects.Neural Regeneration Research,11(4),664-669.
MLA	Muheremu Aikeremujiang,et al."Combined use of Y-tube conduits with human umbilical cord stem cells for repairing nerve bifurcation defects".Neural Regeneration Research 11.4(2016):664-669.