A new and efficient method for the synthesis of rocuronium bromide

CORC > 金属研究所 > 中国科学院金属研究所

	A new and efficient method for the synthesis of rocuronium bromide
	Wu XueYing 2; Wang YaoLing 1; Hai Li 1; Gong Ping 2; Wu Yong 1
刊名	CHINESE CHEMICAL LETTERS
	2017
卷号	28 期号:2 页码:487-492
关键词	ULIPRISTAL ACETATE DERIVATIVES RECEPTORS THIAZOLE PYRAN HL-60 Rocuronium bromide 2 alpha,3 alpha-Epoxy steroid derivative NMBAs Fe-mediated New route
ISSN号	1001-8417
其他题名	A new and efficient method for the synthesis of rocuronium bromide
英文摘要	Rocuronium bromide has been used as an aminosteroid non-depolarizing neuromuscular blocker and muscle relaxant. In this work, a new and efficient route for preparing a key intermediate 2 beta-(4morpholiny1)-16 beta-(1-pyrrolidiny1)-5 alpha-androstan-3 alpha,17 beta-diol (6) was developed through a ring-opening of epoxide followed by introducing and pyrrolidine. Compound 6 can easily provide rocuronium bromide and the overall yield of compound 6 in 5 steps increased to 57.8%, which was higher than currently reported methods. Extraordinarily, this method would avoid the generation of disubstituted impurities E and F which are difficult to remove. (C) 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
资助项目	[National Natural Science Foundation]
语种	英语
CSCD记录号	CSCD:5934409
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/153904]
专题	金属研究所_中国科学院金属研究所
作者单位	1.四川大学 2.中国科学院金属研究所
推荐引用方式 GB/T 7714	Wu XueYing,Wang YaoLing,Hai Li,et al. A new and efficient method for the synthesis of rocuronium bromide[J]. CHINESE CHEMICAL LETTERS,2017,28(2):487-492.
APA	Wu XueYing,Wang YaoLing,Hai Li,Gong Ping,&Wu Yong.(2017).A new and efficient method for the synthesis of rocuronium bromide.CHINESE CHEMICAL LETTERS,28(2),487-492.
MLA	Wu XueYing,et al."A new and efficient method for the synthesis of rocuronium bromide".CHINESE CHEMICAL LETTERS 28.2(2017):487-492.