Design, synthesis and biological evaluation of 1,4-dihydrothieno3 ',2 ':5,6thiopyrano4,3-cpyrazole-3-carboxylic amide derivatives as potential estrogen receptor antagonists

CORC > 金属研究所 > 中国科学院金属研究所

	Design, synthesis and biological evaluation of 1,4-dihydrothieno3 ',2 ':5,6thiopyrano4,3-cpyrazole-3-carboxylic amide derivatives as potential estrogen receptor antagonists
	Sun Rui 1; Song Jing 1; Liu Si Jie 1; Zhao Hui 1; Yan Chun Li 1; Zhang Ai Jun 1; Koirala Diwa 3; Li Da Wei 3; Hu Chun 1
刊名	CHINESE CHEMICAL LETTERS
	2011
卷号	22 期号:3 页码:256-259
关键词	BETA Estrogen receptor antagonists Synthesis Biological activity Thiophene Pyrazole Thiopyran Piperazine
ISSN号	1001-8417
其他题名	Design, synthesis and biological evaluation of 1,4-dihydrothieno3′,2′:5,6thiopyrano4,3- cpyrazole-3-carboxylic amide derivatives as potential estrogen receptor antagonists
英文摘要	The estrogen receptor is a target for therapeutic agents for hormone replacement in menopausal women, osteoporosis, reproductive cancers such as breast cancer, uterine cancer and prostate cancer. 1,4-Dihydrothieno3',2':5,6thiopyrano4,3-cpyrazole-3-carboxylic amide derivatives were designed, synthesized and biological evaluated as potential estrogen receptor antagonists. (C) 2010 Chun Hu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
资助项目	[National Natural Science Foundation of China (NSFC)]
语种	英语
CSCD记录号	CSCD:4149926
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/151613]
专题	金属研究所_中国科学院金属研究所
作者单位	1.上海市地震局 2.中国科学院金属研究所 3.上海交通大学
推荐引用方式 GB/T 7714	Sun Rui,Song Jing,Liu Si Jie,et al. Design, synthesis and biological evaluation of 1,4-dihydrothieno3 ',2 ':5,6thiopyrano4,3-cpyrazole-3-carboxylic amide derivatives as potential estrogen receptor antagonists[J]. CHINESE CHEMICAL LETTERS,2011,22(3):256-259.
APA	Sun Rui.,Song Jing.,Liu Si Jie.,Zhao Hui.,Yan Chun Li.,...&Hu Chun.(2011).Design, synthesis and biological evaluation of 1,4-dihydrothieno3 ',2 ':5,6thiopyrano4,3-cpyrazole-3-carboxylic amide derivatives as potential estrogen receptor antagonists.CHINESE CHEMICAL LETTERS,22(3),256-259.
MLA	Sun Rui,et al."Design, synthesis and biological evaluation of 1,4-dihydrothieno3 ',2 ':5,6thiopyrano4,3-cpyrazole-3-carboxylic amide derivatives as potential estrogen receptor antagonists".CHINESE CHEMICAL LETTERS 22.3(2011):256-259.