Discovery of a new series of imidazo1,2-apyridine compounds as selective c-Met inhibitors

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	Discovery of a new series of imidazo1,2-apyridine compounds as selective c-Met inhibitors
	Liu Tongchao 1; Peng Xia 2; Ma Yuchi 2; Ji Yinchun 2; Chen Danqi 2; Zheng Mingyue 2; Zhao Dongmei 1; Cheng Maosheng 1; Geng Meiyu 2; Shen Jingkang 2
刊名	ACTA PHARMACOLOGICA SINICA
	2016
卷号	37 期号:5 页码:698-707
关键词	RECEPTOR TYROSINE KINASE INVASIVE GROWTH SCATTER FACTOR CANCER DOCKING c-Met inhibitors hepatocyte growth factor receptor imidazo1,2-apyridine anticancer agents drug discovery
ISSN号	1671-4083
其他题名	Discovery of a new series of imidazo1,2-apyridine compounds as selective c-Met inhibitors
英文摘要	Aim: Aberrant c-Met activation plays a critical role in cancer formation, progression and dissemination, as well as in development of resistance to anticancer drugs. Therefore, c-Met has emerged as an attractive target for cancer therapy. The aim of this study was to develop new c-Met inhibitors and elaborate the structure-activity relationships of identified inhibitors.
资助项目	[Foundation of China Postdoctoral Science] ; [National Natural Science Foundation of China] ; [National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program" of China] ; [SA-SIBS Scholarship Program]
语种	英语
CSCD记录号	CSCD:5700554
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/148381]
专题	金属研究所_中国科学院金属研究所
作者单位	1.中国科学院金属研究所 2.中国科学院
推荐引用方式 GB/T 7714	Liu Tongchao,Peng Xia,Ma Yuchi,et al. Discovery of a new series of imidazo1,2-apyridine compounds as selective c-Met inhibitors[J]. ACTA PHARMACOLOGICA SINICA,2016,37(5):698-707.
APA	Liu Tongchao.,Peng Xia.,Ma Yuchi.,Ji Yinchun.,Chen Danqi.,...&Xiong Bing.(2016).Discovery of a new series of imidazo1,2-apyridine compounds as selective c-Met inhibitors.ACTA PHARMACOLOGICA SINICA,37(5),698-707.
MLA	Liu Tongchao,et al."Discovery of a new series of imidazo1,2-apyridine compounds as selective c-Met inhibitors".ACTA PHARMACOLOGICA SINICA 37.5(2016):698-707.