Initiating Characteristics of Early-onset Type 2 Diabetes Mellitus in Chinese Patients

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	Initiating Characteristics of Early-onset Type 2 Diabetes Mellitus in Chinese Patients
	Yu Hui 2; Xie LiFang 3; Chen Kang 2; Yang GangYi 4; Xing XiaoYan 5; Zhao JiaJun 6; Hong TianPei 7; Shan ZhongYan 8; Li HongMei 9; Chen Bing 10
刊名	Chinese Medical Journal
	2016
卷号	129 期号:7 页码:778-784
关键词	Obesity Medicine R Risk Factor Type 2 Diabetes Mellitus Young
ISSN号	0366-6999
其他题名	Initiating Characteristics of Early-onset Type 2 Diabetes Mellitus in Chinese Patients
英文摘要	Background: Type 2 diabetes mellitus (T2DM) has traditionally been considered to affect mainly the elderly; however, the age at diagnosis has gradually reduced in recent years. Although the incidence of young-onset T2DM is increasing, it is still not fully clear the onset characteristics and risk factors of early-onset T2DM. The aim of this study was to describe the initiating characteristics of early-onset T2DM in Chinese patients and evaluate the risk factors for diabetes mellitus. Methods: This cross-sectional controlled study was performed using a questionnaire survey method in outpatients of multiple centers in China. A total of 1545 patients with T2DM with an age at onset of <40 years were included, and the control group consisted of subjects aged <40 years with normal blood glucose level. Results: In patients with young-onset T2DM, the mean age and initial hemoglobin 1Ac at diagnosis were 32.96 ± 5.40 years and 9.59 ± 2.71%, respectively. Most of the patients were obese, followed irregular diet pattern and sedentary lifestyle, had life or work pressure, and had a family history of diabetes mellitus. Compared with subjects with normal blood glucose level, logistic regression analysis showed that waist-to-hip ratio (odds ratio OR 446.99, 95% confidence interval CI 42.37–4714.87), family history of diabetes mellitus (OR 23.46, CI 14.47–38.03), dyslipidemia (OR 2.65, CI 1.54–4.56), diastolic blood pressure (OR 1.02, CI 1.00–1.04), and body mass index (OR 0.95, CI 0.92–0.99) are independent factors for early-onset T2DM. Conclusions: We observed that abdominal obesity, family history of diabetes mellitus, and medical history of hypertension and dyslipidemia are independent risk factors for early-onset T2DM. It is, therefore, necessary to apply early lifestyle intervention in young people with risk of diabetes mellitus.
资助项目	[National Science and Technology Major Project]
语种	英语
CSCD记录号	CSCD:5674625
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/144171]
专题	金属研究所_中国科学院金属研究所
作者单位	1.Shanxi Med University, Hosp 1, Dept Endocrinol, Taiyuan 030001, Shanxi, Peoples R China 2.中国人民解放军总医院 3.Chinese Peoples Liberat Army 155 Hosp, Department Endocrinol, Kaifeng 475003, Henan, Peoples R China Department Endocrinol 4.Chongqing Med University, Affiliated Hosp 2, Dept Endocrinol, Chongqing 400010, Peoples R China 5.China Japan Friendship Hosp, Department Endocrinol, Beijing 100029, Peoples R China 6.山东大学 7.北京大学 8.中国科学院金属研究所 9.China Meitan Gen Hosp, Department Endocrinol, Beijing 100028, Peoples R China 10.Third Mil Med University, Southwest Hosp, Dept Endocrinol & Metab, Chongqing 400038, Peoples R China
推荐引用方式 GB/T 7714	Yu Hui,Xie LiFang,Chen Kang,et al. Initiating Characteristics of Early-onset Type 2 Diabetes Mellitus in Chinese Patients[J]. Chinese Medical Journal,2016,129(7):778-784.
APA	Yu Hui.,Xie LiFang.,Chen Kang.,Yang GangYi.,Xing XiaoYan.,...&Mu YiMing.(2016).Initiating Characteristics of Early-onset Type 2 Diabetes Mellitus in Chinese Patients.Chinese Medical Journal,129(7),778-784.
MLA	Yu Hui,et al."Initiating Characteristics of Early-onset Type 2 Diabetes Mellitus in Chinese Patients".Chinese Medical Journal 129.7(2016):778-784.