MAGNOLOL ENTRAPPED ULTRA-FINE FIBROUS MATS ELECTROSPUN FROM POLY(ETHYLENE GLYCOL)-b-POLY(L-LACTIDE) AND IN VITRO RELEASE

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	MAGNOLOL ENTRAPPED ULTRA-FINE FIBROUS MATS ELECTROSPUN FROM POLY(ETHYLENE GLYCOL)-b-POLY(L-LACTIDE) AND IN VITRO RELEASE
	Wang Hao 1; Song Hongrui 1; Cui Yong 1; Deng Yingjie 1; Chen Xuesi 2
刊名	CHINESE JOURNAL OF POLYMER SCIENCE
	2011
卷号	29 期号:2 页码:173-179
关键词	BIOMEDICAL APPLICATIONS BLOCK-COPOLYMERS FIBERS GLYCOL) ACID) Medicated fiber Electrospinning Drug release Poly(ethylene glycol) Polylactide Magnolol Proteinase K
ISSN号	0256-7679
英文摘要	Ultra-fine fibrous mats with magnolol entrapped have been prepared by electrospinning biodegradable copolymer poly(ethylene glycol) blocked poly(L-lactide). Drug entrapment was perfect which was confirmed by scanning electron microscopy and differential scanning calorimetry. According to in vitro drug release investigation by high performance liquid chromatography, it was found that fibers with 10%, 20% and 30% drug entrapped respect to polymer (mass ratio) presented dramatically different drug release behavior and degradation behavior under the effect of proteinase K. The reason may be that fibers with 10% drug entrapped was more easily affected by enzyme while, to some degree, magnolol in fibers with 20% and 30% entrapped prevented polymer from being degraded by enzyme.
资助项目	[National Natural Science Foundation of China] ; [Chinese Academy of Sciences]
语种	英语
CSCD记录号	CSCD:4144350
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/141901]
专题	金属研究所_中国科学院金属研究所
作者单位	1.中国科学院金属研究所 2.中山大学
推荐引用方式 GB/T 7714	Wang Hao,Song Hongrui,Cui Yong,et al. MAGNOLOL ENTRAPPED ULTRA-FINE FIBROUS MATS ELECTROSPUN FROM POLY(ETHYLENE GLYCOL)-b-POLY(L-LACTIDE) AND IN VITRO RELEASE[J]. CHINESE JOURNAL OF POLYMER SCIENCE,2011,29(2):173-179.
APA	Wang Hao,Song Hongrui,Cui Yong,Deng Yingjie,&Chen Xuesi.(2011).MAGNOLOL ENTRAPPED ULTRA-FINE FIBROUS MATS ELECTROSPUN FROM POLY(ETHYLENE GLYCOL)-b-POLY(L-LACTIDE) AND IN VITRO RELEASE.CHINESE JOURNAL OF POLYMER SCIENCE,29(2),173-179.
MLA	Wang Hao,et al."MAGNOLOL ENTRAPPED ULTRA-FINE FIBROUS MATS ELECTROSPUN FROM POLY(ETHYLENE GLYCOL)-b-POLY(L-LACTIDE) AND IN VITRO RELEASE".CHINESE JOURNAL OF POLYMER SCIENCE 29.2(2011):173-179.