The mechanical property and corrosion resistance of Mg-Zn-Nd alloy fine wires in vitro and in vivo

doi:10.1016/j.bioactmat.2020.07.011

CORC > 金属研究所 > 中国科学院金属研究所

	The mechanical property and corrosion resistance of Mg-Zn-Nd alloy fine wires in vitro and in vivo
	Gao, Ming 1,3; Na, Di 2; Ni, Xiangqiao 2; Song, Lihui 2; Etim, Iniobong P.1,3; Yang, Ke 1; Tan, Lili 1; Ma, Zheng 1
刊名	BIOACTIVE MATERIALS
	2021
卷号	6 期号:1 页码:55-63
关键词	Magnesium Surgical staple Anastomosis Corrosion resistance In vivo
DOI	10.1016/j.bioactmat.2020.07.011
通讯作者	Tan, Lili(lltan@imr.ac.cn) ; Ma, Zheng(zma@imr.ac.cn)
英文摘要	Titanium and its alloy are commonly used as surgical staples in the reconstruction of intestinal tract and stomach, however they cannot be absorbed in human body, which may cause a series of complications to influence further diagnosis. Magnesium and its alloy have great potential as surgical staples, because they can be degraded in human body and have good mechanical properties and biocompatibility. In this study, Mg-2Zn-0.5Nd (ZN20) alloy fine wires showed great potential as surgical staples. The ultimate tensile strength and elongation of ZN20 alloy fine wires were 248 MPa and 13%, respectively, which could be benefit for the deformation of the surgical staples from U-shape to B-shape. The bursting pressure of the wire was about 40 kPa, implying that it can supply sufficient mechanical support after anastomosis. Biochemical test and histological analysis illustrated good biocompatibility and biological safety of ZN20 alloy fine wire. The residual tensile stress formed on the outside of ZN20 fine wire during drawing would accelerate the corrosion. The second phase had a negative influence on corrosion property due to galvanic corrosion. The corrosion rate in vitro was faster than that in vivo due to the capsule formed on the surface of ZN20 alloy fine wire.
资助项目	Key Program of China on Biomedical Materials Research and Tissue Organ Replacement[2016YFC1101804] ; Key Program of China on Biomedical Materials Research and Tissue Organ Replacement[2016YFC1100604] ; National Natural Science Foundation of China[51971222] ; National Natural Science Foundation of China[51801220]
WOS研究方向	Engineering ; Materials Science
语种	英语
出版者	KEAI PUBLISHING LTD
WOS记录号	WOS:000574616100005
资助机构	Key Program of China on Biomedical Materials Research and Tissue Organ Replacement ; National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/140749]
专题	金属研究所_中国科学院金属研究所
通讯作者	Tan, Lili; Ma, Zheng
作者单位	1.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 2.China Med Univ, Dept Surg Oncol, Hosp 1, Shenyang, Liaoning, Peoples R China 3.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Peoples R China
推荐引用方式 GB/T 7714	Gao, Ming,Na, Di,Ni, Xiangqiao,et al. The mechanical property and corrosion resistance of Mg-Zn-Nd alloy fine wires in vitro and in vivo[J]. BIOACTIVE MATERIALS,2021,6(1):55-63.
APA	Gao, Ming.,Na, Di.,Ni, Xiangqiao.,Song, Lihui.,Etim, Iniobong P..,...&Ma, Zheng.(2021).The mechanical property and corrosion resistance of Mg-Zn-Nd alloy fine wires in vitro and in vivo.BIOACTIVE MATERIALS,6(1),55-63.
MLA	Gao, Ming,et al."The mechanical property and corrosion resistance of Mg-Zn-Nd alloy fine wires in vitro and in vivo".BIOACTIVE MATERIALS 6.1(2021):55-63.