In vitro degradation and biocompatibility evaluation of fully biobased thermoplastic elastomers consisting of poly(beta-myrcene) and poly(L-lactide) as stent coating

doi:10.1016/j.polymdegradstab.2020.109254

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	In vitro degradation and biocompatibility evaluation of fully biobased thermoplastic elastomers consisting of poly(beta-myrcene) and poly(L-lactide) as stent coating
	Wei, Zhiyong 1; Wang, Wenhuan 1; Zhou, Cheng 1; Jin, Chenhao 1; Leng, Xuefei 1; Li, Yang 1; Zhang, Xing 2,3; Chen, Shanshan 3; Zhang, Bingchun 3; Yang, Ke 3
刊名	POLYMER DEGRADATION AND STABILITY
	2020-09-01
卷号	179 页码:10
关键词	Drug eluting stent Coating Poly(beta-myrcene)-poly(L-lactide) Thermoplastic elastomers
ISSN号	0141-3910
DOI	10.1016/j.polymdegradstab.2020.109254
通讯作者	Leng, Xuefei(lengxuefei@dlut.edu.cn) ; Chen, Shanshan(sschen@imr.ac.cn)
英文摘要	Currently coronary stent coating materials focus on biodegradable polymers requiring excellent performances, including biodegradability, cytocompatibility and hemocompatibility as well as ductility. To endow poly(L-lactide) (PLLA) with good ductility as stent coating, two kinds of high branched PLLA grafted copolymers with introduction of biobased poly(beta-myrcene) rubber segments were developed towards sent coating. The impacts of topological architectures (including linear comb and star comb) on physical properties, hydrolytic and enzymatic degradation behaviors, cytocompatibility, hemocompatibility and coating morphology were investigated. It was found that the nonbiodegradable poly(beta-myrcene) rubber segments delayed the degradation rate, and further decreased with more complex architectures. Proteinase K accelerated enzymatic degradation compared with hydrolytic degradation. Biocompatibility testing showed that the fully biobased thermoplastic elastomers possessed good cytocompatibility and hemocompatibility. Morphological characterization of stent coatings indicated that the linear comb and star comb PLLA grafted copolymers improved the surface smooth of pure PLLA coating. Thus, these highly branched fully biobased thermoplastic elastomers are promising to as potential coating materials in drug eluting stent. (C) 2020 Elsevier Ltd. All rights reserved.
资助项目	National Key R&D Program of China[2018YFC1105500 (2018YFC1105503)] ; Joint Research Fund Liaoning-Shenyang National Laboratory for Materials Science[20180510037] ; Fundamental Research Funds for the Central Universities[DUT19LAB27]
WOS研究方向	Polymer Science
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000564499500004
资助机构	National Key R&D Program of China ; Joint Research Fund Liaoning-Shenyang National Laboratory for Materials Science ; Fundamental Research Funds for the Central Universities
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/140434]
专题	金属研究所_中国科学院金属研究所
通讯作者	Leng, Xuefei; Chen, Shanshan
作者单位	1.Dalian Univ Technol, Sch Chem Engn, Dept Polymer Sci & Engn, State Key Lab Fine Chem,Liaoning Key Lab Polymer, Dalian 116024, Peoples R China 2.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Liaoning, Peoples R China 3.Chinese Acad Sci, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Peoples R China
推荐引用方式 GB/T 7714	Wei, Zhiyong,Wang, Wenhuan,Zhou, Cheng,et al. In vitro degradation and biocompatibility evaluation of fully biobased thermoplastic elastomers consisting of poly(beta-myrcene) and poly(L-lactide) as stent coating[J]. POLYMER DEGRADATION AND STABILITY,2020,179:10.
APA	Wei, Zhiyong.,Wang, Wenhuan.,Zhou, Cheng.,Jin, Chenhao.,Leng, Xuefei.,...&Yang, Ke.(2020).In vitro degradation and biocompatibility evaluation of fully biobased thermoplastic elastomers consisting of poly(beta-myrcene) and poly(L-lactide) as stent coating.POLYMER DEGRADATION AND STABILITY,179,10.
MLA	Wei, Zhiyong,et al."In vitro degradation and biocompatibility evaluation of fully biobased thermoplastic elastomers consisting of poly(beta-myrcene) and poly(L-lactide) as stent coating".POLYMER DEGRADATION AND STABILITY 179(2020):10.