Effects of collimated and focused low-intensity pulsed ultrasound stimulation on the mandible repair in rabbits

doi:10.21037/atm.2019.12.89

CORC > 金属研究所 > 中国科学院金属研究所

	Effects of collimated and focused low-intensity pulsed ultrasound stimulation on the mandible repair in rabbits
	Liu, Xiaohan 2; Hu, Ying 3; Wu, Lin 2; Li, Shujun 1
刊名	ANNALS OF TRANSLATIONAL MEDICINE
	2020-02-01
卷号	8 期号:4 页码:9
关键词	Osteogenesis low-intensity collimated pulse ultrasound (LICU) low-intensity focused-pulse ultrasound (LIFU) porous SiC scaffold
ISSN号	2305-5839
DOI	10.21037/atm.2019.12.89
通讯作者	Wu, Lin(wulin13@163.com)
英文摘要	Background: This study was to evaluate the effects of low-intensity collimated pulse ultrasound (LICU) and low-intensity focused-pulse ultrasound (LIFU) stimulation on the osteogenesis in the porous silicon carbide (SiC) scaffold implanted in the rabbit mandible. Methods: Rabbits were randomly divided into LIFU group, LICU group and control group (without ultrasound treatment). The intensities of LICU and LIFU were 30 and 300 mW/cm(2), respectively. The subcutaneous and subperiosteal temperatures were measured continuously during the 20-min ultrasound treatment. Then, the porous SiC scaffolds were implanted into the mandible, followed by LICU or LIFU once daily, and the quantity and structure of bone were assessed by methylene blue-acid fuchsin staining and micro-CT at 3, 6 and 9 weeks after implantation. Results: The changes in the subcutaneous and subperiosteal temperatures during LICU and LIFU were less than 1 degrees C. The bone mass increased and the structure of bone tissues became more mature over time. The bone mass and mean pore occupancy fraction (POF) in the LIFU group were significantly greater than in the LICU group at three time points (P<0.05). Bone ingrowth in different directions was observed, and the new bone formation in the mesial, distal, top, and lingual sides of the implants in the LIFU group was greater than in the LICU group and control group (P<0.05). Conclusions: LIEU and LICU may effectively promote bone formation in the mandible scaffold, and LIFU significantly accelerates bone formation in both buccal side and lingual side of the scaffold.
资助项目	National Natural Science Foundation of China (NSFC)[81870811] ; Natural Science Foundation of the Higher Education Institutions of Liaoning Province[LQNK201722]
WOS研究方向	Oncology ; Research & Experimental Medicine
语种	英语
出版者	AME PUBL CO
WOS记录号	WOS:000518410000050
资助机构	National Natural Science Foundation of China (NSFC) ; Natural Science Foundation of the Higher Education Institutions of Liaoning Province
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/137558]
专题	金属研究所_中国科学院金属研究所
通讯作者	Wu, Lin
作者单位	1.Chinese Acad Sci, Inst Met Res, Shenyang Natl Lab Mat Sci, Shenyang 110016, Peoples R China 2.China Med Univ, Sch & Hosp Stomatol, Dept Prosthodont, Liaoning Prov Key Lab Oral Dis, Shenyang 110002, Peoples R China 3.Dalian Stomatol Hosp, Dept Pediat Dent, Dalian 116021, Peoples R China
推荐引用方式 GB/T 7714	Liu, Xiaohan,Hu, Ying,Wu, Lin,et al. Effects of collimated and focused low-intensity pulsed ultrasound stimulation on the mandible repair in rabbits[J]. ANNALS OF TRANSLATIONAL MEDICINE,2020,8(4):9.
APA	Liu, Xiaohan,Hu, Ying,Wu, Lin,&Li, Shujun.(2020).Effects of collimated and focused low-intensity pulsed ultrasound stimulation on the mandible repair in rabbits.ANNALS OF TRANSLATIONAL MEDICINE,8(4),9.
MLA	Liu, Xiaohan,et al."Effects of collimated and focused low-intensity pulsed ultrasound stimulation on the mandible repair in rabbits".ANNALS OF TRANSLATIONAL MEDICINE 8.4(2020):9.