Interactions of polymeric drug carriers with DDT reduce their combined cytotoxicity

doi:10.1016/j.envpol.2018.06.010

CORC > 金属研究所 > 中国科学院金属研究所

	Interactions of polymeric drug carriers with DDT reduce their combined cytotoxicity
	Zhang, Xuejiao 3; Lei, Lei 2,3; Zhang, Haiyan 4; Zhang, Siyu 3,5; Xing, Weiwei 1; Wang, Jin 1; Li, Haibo 4,5; Zhao, Qing 3; Xing, Baoshan 5
刊名	ENVIRONMENTAL POLLUTION
	2018-10-01
卷号	241 页码:701-709
关键词	Polymeric nanomicelles Organic pollutants Partitioning behavior Combined cytotoxicity Biointerfacial behavior
ISSN号	0269-7491
DOI	10.1016/j.envpol.2018.06.010
通讯作者	Zhao, Qing(zhaoqing@iae.ac.cn)
英文摘要	Attention has been paid to the environmental distribution and fate of nanomedicines. However, their effects on the toxicity of environmental pollutants are lack of knowledge. In this study, the negatively charged poly (ethylene glycol)-b-poly (L-lactide-co-glycolide) (mPEG-PLA) and positively charged polyethyleneimine-palmitate (PEI-PA) nanomicelles were synthesized and served as model drug carriers to study the interaction and combined toxicity with dichlorodiphenyltrichloroethane (DDT). DDT exerted limited effect on the biointerfacial behavior of mPEG-PLA nanomicelles, whereas it significantly mitigated the attachment of PEI-PA nanomicelles on the model cell membrane as monitored by quartz crystal microbalance with dissipation (QCM-D). The cytotoxicity of DDT towards NIH 3T3 cells was greatly decreased by either co-treatment or pre-treatment with the nanomicelles according to the results of real-time cell analysis (RICA). The cell viability of NIH 3T3 exposed to DDT was increased up to 90% by the co-treatment with mPEG-PLA nanomicelles. Three possible reasons were proposed: (1) decreased amount of free DDT in the cell culture medium due to the partitioning of DDT into nanomicelles; (2) mitigated cellular uptake of nanomicelle-DDT complexes due to the complex agglomeration or electrostatic repulsion between complexes and cell membrane; (3) detoxification effect in the lysosome upon endocytosis of nanomicelle-DDT complexes. (C) 2018 Elsevier Ltd. All rights reserved.
资助项目	National Natural Science Foundation of China[41603120] ; National Natural Science Foundation of China[41703107] ; National Natural Science Foundation of China[21671115] ; National Key Research and Development Program of China[2016YFD0800300] ; Youth Innovation Promotion Association CAS ; Key Laboratory of Industrial Ecology and Environmental Engineering (MOE) ; Hundreds Talents Program of Chinese Academy of Sciences
WOS研究方向	Environmental Sciences & Ecology
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000440390800075
资助机构	National Natural Science Foundation of China ; National Key Research and Development Program of China ; Youth Innovation Promotion Association CAS ; Key Laboratory of Industrial Ecology and Environmental Engineering (MOE) ; Hundreds Talents Program of Chinese Academy of Sciences
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/129046]
专题	金属研究所_中国科学院金属研究所
通讯作者	Zhao, Qing
作者单位	1.Liaoning Beifang Environm Technol Co LTD, Shenyang 110161, Liaoning, Peoples R China 2.Univ Chinese Acad Sci, Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Appl Ecol, Key Lab Pollut Ecol & Environm Engn, Shenyang, Liaoning, Peoples R China 4.Northeastern Univ, Sch Resources & Civil Engn, Shenyang 110004, Liaoning, Peoples R China 5.Univ Massachusetts, Stockbridge Sch Agr, Amherst, MA 01003 USA
推荐引用方式 GB/T 7714	Zhang, Xuejiao,Lei, Lei,Zhang, Haiyan,et al. Interactions of polymeric drug carriers with DDT reduce their combined cytotoxicity[J]. ENVIRONMENTAL POLLUTION,2018,241:701-709.
APA	Zhang, Xuejiao.,Lei, Lei.,Zhang, Haiyan.,Zhang, Siyu.,Xing, Weiwei.,...&Xing, Baoshan.(2018).Interactions of polymeric drug carriers with DDT reduce their combined cytotoxicity.ENVIRONMENTAL POLLUTION,241,701-709.
MLA	Zhang, Xuejiao,et al."Interactions of polymeric drug carriers with DDT reduce their combined cytotoxicity".ENVIRONMENTAL POLLUTION 241(2018):701-709.