Wolfberry extracts inhibit Aˇ1-42aggregation and rescue memory lossof AD drosophila | |
Li CH(李彩虹)1,2; Yang JL(杨军丽)1 | |
刊名 | Food Science and Human Wellness |
2020 | |
卷号 | 9期号:1页码:64–70 |
关键词 | Aˇ1−42 Antioxidant bioactivity Anti-AD potential Bio-metal Drosophila Wolfberry |
DOI | doi.org/10.1016/j.fshw.2019.12.007 |
英文摘要 | This study is to investigate the potential of wolfberry water extracts for the treatment of Alzheimer’s disease (AD) and the relationship between their anti-AD property and the geographic locations in China. Total extracts of all wolfberry samples showed the potent to decrease self-induced Aβ1-42 aggregation and Cu2+-induced Aβ1-42 aggregation and the antioxidant capacity as well as the bioactivity for binding bio-metal. A transgenic drosophila model assay revealed that TE of S1 and S6 (S1-TE and S6-TE) at 100 μg/mL demonstrated the potent rescue effect on memory loss compared to the positive control memantine at 20 μg/mL. Further study also revealed the polysaccharide extracts could contribute to their anti-AD property, and the anti-AD activity conspicuously depends on growing environment. Wolfberry samples S1 and S6 showed much more potent anti-AD property. Meanwhile this study demonstrated that the Chinese commonly consumed wolfberry in boiling water might have the beneficial function to prevent AD pathology. |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://ir.licp.cn/handle/362003/26516] |
专题 | 兰州化学物理研究所_中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
通讯作者 | Yang JL(杨军丽) |
作者单位 | 1.Lanzhou Institute ofChemical Physics (LICP), Chinese Academy of Sciences (CAS) 2.ChinabUniversity of Chinese Academy of Sciences |
推荐引用方式 GB/T 7714 | Li CH,Yang JL. Wolfberry extracts inhibit Aˇ1-42aggregation and rescue memory lossof AD drosophila[J]. Food Science and Human Wellness,2020,9(1):64–70. |
APA | Li CH,&Yang JL.(2020).Wolfberry extracts inhibit Aˇ1-42aggregation and rescue memory lossof AD drosophila.Food Science and Human Wellness,9(1),64–70. |
MLA | Li CH,et al."Wolfberry extracts inhibit Aˇ1-42aggregation and rescue memory lossof AD drosophila".Food Science and Human Wellness 9.1(2020):64–70. |
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