Cytotoxicity of PM2.5 vehicular emissions in the Shing Mun Tunnel, Hong Kong

doi:10.1016/j.envpol.2020.114386

CORC > 地球环境研究所 > 中国科学院地球环境研究所 > 粉尘与环境研究室

	Cytotoxicity of PM2.5 vehicular emissions in the Shing Mun Tunnel, Hong Kong
	Niu, Xinyi 6; Chuang, Hsiao-Chi 7; Wang, Xiaoliang 9; Ho, Steven Sai Hang 3,9; Li, Lijuan 4,5,8; Qu, Linli 3; Chow, Judith C.9; Watson, John G.9; Sun, Jian 2; Lee, Shuncheng 1
刊名	ENVIRONMENTAL POLLUTION
	2020-08-01
卷号	263 页码:9
关键词	Respiratory effects Cytokines Bioreactivity Oxidative stress Inflammation potential
ISSN号	0269-7491
DOI	10.1016/j.envpol.2020.114386
通讯作者	Ho, Kin Fai(kfho@cuhk.edu.hk)
英文摘要	Associations between human exposures to vehicular emissions (VE) and cardiopulmonary diseases have been found, with a dearth of information on particle cytotoxicity. This study exposes human lung alveolar epithelial (A549) cells to PM2.5 (particulate matter with aerodynamic diameter < 2.5 mu m) samples collected in a tunnel and investigates the oxidative and inflammatory responses. The cytotoxicity factor (CF) is used to normalize the VE cytotoxicity. The emission factors (EFs) were 27.2 +/- 12.0 mg vehicle(-1) km(-1) for PM2.5 and 4.93 +/- 1.67 mu g vehicle(-1) km(-1) for measured polycyclic aromatic hydrocarbons (PAHs). Higher EFs were found for high (4-6 rings) than low (2-3 rings) molecular-weight particulate PAHs. PM2.5 VE caused oxidative stress and inflammation of human lung cells. Organic carbon (OC), element carbon (EC), and several PAHs were significantly (p < 0.05) correlated with bioreactivity. Higher CFs were found when diesel vehicle counts were highest during the morning rush hour, implying that diesel-fueled VE were major contributors to cytotoxic effects. This study provides a broader understanding of the toxicity in an engine-exhaust dominated environment. (c) 2020 Elsevier Ltd. All rights reserved.
资助项目	Research Grant Council of The Hong Kong Special Administrative Region China ; CUHK[14202817] ; U.S. Health Effects Institute[4947-RFPA14-1/15-1]
WOS关键词	POLYCYCLIC AROMATIC-HYDROCARBONS ; AMBIENT PARTICULATE MATTER ; PORT THERMAL-DESORPTION ; ORGANIC-COMPOUNDS VOCS ; OXIDATIVE STRESS ; AIR-POLLUTION ; IN-VITRO ; RESPIRATORY SYMPTOMS ; CHEMICAL-COMPOSITION ; NOX EMISSIONS
WOS研究方向	Environmental Sciences & Ecology
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000539426400058
资助机构	Research Grant Council of The Hong Kong Special Administrative Region China ; CUHK ; U.S. Health Effects Institute
内容类型	期刊论文
源URL	[http://ir.ieecas.cn/handle/361006/14941]
专题	地球环境研究所_粉尘与环境研究室
通讯作者	Ho, Kin Fai
作者单位	1.Hong Kong Polytech Univ, Dept Civil & Environm Engn, Hong Kong, Peoples R China 2.Xi An Jiao Tong Univ, Sch Human Settlements & Civil Engn, Xian 710049, Shaanxi, Peoples R China 3.Hong Kong Premium Serv & Res Lab, Hong Kong, Peoples R China 4.Chinese Acad Sci, Inst Earth Environm, State Key Lab Loess & Quaternary Geol SKLLQG, Xian, Peoples R China 5.Chinese Acad Sci, Inst Earth Environm, Key Lab Aerosol Chem & Phys, Xian, Peoples R China 6.Chinese Univ Hong Kong, Jockey Club Sch Publ Hlth & Primary Care, Hong Kong, Peoples R China 7.Taipei Med Univ, Sch Resp Therapy, Coll Med, Taipei, Taiwan 8.Univ Chinese Acad Sci, Beijing, Peoples R China 9.Desert Res Inst, Div Atmospher Sci, Reno, NV 89512 USA
推荐引用方式 GB/T 7714	Niu, Xinyi,Chuang, Hsiao-Chi,Wang, Xiaoliang,et al. Cytotoxicity of PM2.5 vehicular emissions in the Shing Mun Tunnel, Hong Kong[J]. ENVIRONMENTAL POLLUTION,2020,263:9.
APA	Niu, Xinyi.,Chuang, Hsiao-Chi.,Wang, Xiaoliang.,Ho, Steven Sai Hang.,Li, Lijuan.,...&Ho, Kin Fai.(2020).Cytotoxicity of PM2.5 vehicular emissions in the Shing Mun Tunnel, Hong Kong.ENVIRONMENTAL POLLUTION,263,9.
MLA	Niu, Xinyi,et al."Cytotoxicity of PM2.5 vehicular emissions in the Shing Mun Tunnel, Hong Kong".ENVIRONMENTAL POLLUTION 263(2020):9.