The nature of how the El Nino-Southern Oscillation (ENSO) and its seasonality respond to warmer climate is critical knowledge to predict future climates under the expected anthropogenic warming scenario. In this study, a sub-fossil Tridacna gigas specimen was collected from the northern SCS and AMS¹⁴C dating suggested that the animal lived around AD 1099, during the Medieval Climate Anomaly (MCA) interval, the most recent natural warm period of the late Holocene. Monthly Sr/Ca ratios were determined by the ICP-OES measurements and a 30-year long SST record was calculated based on a Sr/Ca-SST calibration equation. The results showed that the SST seasonality for this 30-year window around AD 1099 was about 3.11 [degree]C, which is smaller than the modern warm period (i.e., about 4.36 [degree]C for AD 1994 [approximately] 2005 interval). This new result is consistent with another published Tridacna gigas record that was dated around AD 990 from the northern SCS. The signals of ENSO activity were also extracted from the reconstructed SST record and statistical analyses yielded 9 El Nino events and 8 La Nina events within the 30-year record, indicating that the frequency of ENSO activity around AD 1099 was similar to the modern instrumental period.