Comparative toxicokinetics and tissue distribution of prothioconazole and prothioconazole-desthio in Chinese lizards (Eremias argus) and transcriptional responses of metabolic-related genes

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 中国科学院环境生物技术重点实验室

	Comparative toxicokinetics and tissue distribution of prothioconazole and prothioconazole-desthio in Chinese lizards (Eremias argus) and transcriptional responses of metabolic-related genes
	Xie, Yun ; Li, Leon Yu Zheng ; Hao, Weiyu ; Chang, Jing ; Xu, Peng ; Guo, Baoyuan ; Li, Jianzhong ; Wang, Huili
刊名	ENVIRONMENTAL POLLUTION
	2019-04-01
卷号	247 页码:524-533
关键词	Eremias argus Prothioconazole Toxicokinetics Enantioselective CYP450 gene expression
ISSN号	0269-7491
英文摘要	Prothioconazole (PTC) is a widely used triazolinthione fungicide with low toxicity and short residual period. However, its desulfurization metabolite, prothioconazole-desthio (PTC-d), is more persistent and has higher toxicity in terrestrial animals. In this study, the toxicokinetics (TK) and tissue distribution of PTC and PTC-d in Chinese lizards (Eremias argus) were measured following single oral dose (100 mg kg(-1) body weight) treatments. TK parameters indicated that PTC was more rapidly absorbed than PTC-d, as indicated by its shorter time to reach peak concentrations in most tissues. Furthermore, the relative bioavailability of PTC in lizards was lower than that of PTC-d. Compared with PTC, PTC-d preferentially accumulated in lizards, as reflected by longer half-life of PTC-d. During the distribution process, PTC-d generated in vivo was transported from other tissues and was deposited in the skin and tail, where PTC-d may be excreted by exuviation or tail detachment. Preferential enrichment of S-enantiomer of both PTC and PTC-d were observed in all tissues. Hepatic cytochrome P450 gene expression measurement revealed that cyp1a5 and cyp3a28 exhibited the strongest responses in both treatment groups. In addition, the opposite responses of cyp2k4 in different treatment groups may indicate that this enzyme caused differences in the rates of metabolism of the two chemicals. This study compared the TK profile of PTC and its desulfurization metabolite PTC-d in lizards and demonstrated that the desulfurization of PTC could increase its ecological risk due to the higher bioavailability and persistence of PTC-d. (C) 2019 Elsevier Ltd. All rights reserved.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/43345]
专题	生态环境研究中心_中国科学院环境生物技术重点实验室
作者单位	1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Shuangqing RD 18, Beijing 100085, Peoples R China 2.Univ Chinese Acad Sci, Yuquan RD 19A, Beijing 100049, Peoples R China 3.Univ Oxford, Dept Zool, Oxford OX1 3PS, England
推荐引用方式 GB/T 7714	Xie, Yun,Li, Leon Yu Zheng,Hao, Weiyu,et al. Comparative toxicokinetics and tissue distribution of prothioconazole and prothioconazole-desthio in Chinese lizards (Eremias argus) and transcriptional responses of metabolic-related genes[J]. ENVIRONMENTAL POLLUTION,2019,247:524-533.
APA	Xie, Yun.,Li, Leon Yu Zheng.,Hao, Weiyu.,Chang, Jing.,Xu, Peng.,...&Wang, Huili.(2019).Comparative toxicokinetics and tissue distribution of prothioconazole and prothioconazole-desthio in Chinese lizards (Eremias argus) and transcriptional responses of metabolic-related genes.ENVIRONMENTAL POLLUTION,247,524-533.
MLA	Xie, Yun,et al."Comparative toxicokinetics and tissue distribution of prothioconazole and prothioconazole-desthio in Chinese lizards (Eremias argus) and transcriptional responses of metabolic-related genes".ENVIRONMENTAL POLLUTION 247(2019):524-533.