Improved Healing of Diabetic Foot Ulcer upon Oxygenation Therapeutics through Oxygen-Loading Nanoperfluorocarbon Triggered by Radial Extracorporeal Shock Wave

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Improved Healing of Diabetic Foot Ulcer upon Oxygenation Therapeutics through Oxygen-Loading Nanoperfluorocarbon Triggered by Radial Extracorporeal Shock Wave
	Wang, Shunhao 3; Yin, Chunyang 3; Han, Xiaoguang 4; Guo, Anyi 4; Chen, Xiaodong 1; Liu, Sijin 3; Liu, Yajun 4
刊名	OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
	2019-08-14
卷号	2019 页码:-
ISSN号	1942-0900
英文摘要	Diabetic foot ulcers (DFUs), the most serious complication of diabetes mellitus, can induce high morbidity, the need to amputate lower extremities, and even death. Although many adjunctive strategies have been applied for the treatment of DFUs, the low treatment efficiency, potential side effects, and high cost are still huge challenges. Recently, nanomaterial-based drug delivery systems (NDDSs) have achieved targeted drug delivery and controlled drug release, offering great promises in various therapeutics for diverse disorders. Additionally, the radial extracorporeal shock wave (rESW) has been shown to function as a robust trigger source for the NDDS to release its contents, as the rESW harbors a potent capability in generating pressure waves and in creating the cavitation effect. Here, we explored the performance of oxygen-loaded nanoperfluorocarbon (Nano-PFC) combined with the rESW as a treatment for DFUs. Prior to in vivo assessment, we first demonstrated the high oxygen affinity in vitro and great biocompatibility of Nano-PFC. Moreover, the rESW-responsive oxygen release behavior from oxygen-saturated Nano-PFC was also successfully verified in vitro and in vivo. Importantly, the wound healing of DFUs was significantly accelerated due to improved blood microcirculation, which was a result of rESW therapy (rESWT), and the targeted release of oxygen into the wound from oxygen-loaded Nano-PFC, which was triggered by the rESW. Collectively, the oxygen-saturated Nano-PFC and rESW provide a completely new approach to treat DFUs, and this study highlights the advantages of combining nanotechnology with rESW in therapeutics.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/42550]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
作者单位	1.Peking Univ, Hlth Sci Ctr, Clin Hosp 4, Beijing Jishuitan Hosp, Beijing 100035, Peoples R China 2.Beijing Inst Technol, Sch Aerosp Engn, Beijing 100081, Peoples R China 3.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wang, Shunhao,Yin, Chunyang,Han, Xiaoguang,et al. Improved Healing of Diabetic Foot Ulcer upon Oxygenation Therapeutics through Oxygen-Loading Nanoperfluorocarbon Triggered by Radial Extracorporeal Shock Wave[J]. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY,2019,2019:-.
APA	Wang, Shunhao.,Yin, Chunyang.,Han, Xiaoguang.,Guo, Anyi.,Chen, Xiaodong.,...&Liu, Yajun.(2019).Improved Healing of Diabetic Foot Ulcer upon Oxygenation Therapeutics through Oxygen-Loading Nanoperfluorocarbon Triggered by Radial Extracorporeal Shock Wave.OXIDATIVE MEDICINE AND CELLULAR LONGEVITY,2019,-.
MLA	Wang, Shunhao,et al."Improved Healing of Diabetic Foot Ulcer upon Oxygenation Therapeutics through Oxygen-Loading Nanoperfluorocarbon Triggered by Radial Extracorporeal Shock Wave".OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2019(2019):-.