Extracting biomolecule collision cross sections from FT-ICR mass spectral line shape

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Extracting biomolecule collision cross sections from FT-ICR mass spectral line shape
	Tang, Yang ; Li, Dayu 2; Cao, Dong 3; Xu, Wei
刊名	TALANTA
	2019-12-01
卷号	205 页码:-
ISSN号	0039-9140
英文摘要	To extend the ion structure analysis capability of Fourier transform mass spectrometry (FT-MS), both time-domain and frequency-domain methods have been developed to extract ion collision cross sections (CCS) from high resolution mass spectra in Fourier transform ion cyclotron resonance (FT-ICR) cells. In this study, a new frequency-domain method, namely the line shape fitting method, was proposed to calculate ion CCSs from FT-ICR mass spectra line shape. Besides experimental data, simulated data with precisely controlled signal to noise levels and decay factors were also applied to characterize this method. Compared with the linewidth correction method previously proposed by our group, this line shape fitting method is more tolerant to noise, data length, and sampling rate, thus providing more consistent results. More importantly, CCS measurements of angiotensin I, bradykinin, ubiquitin and cytochrome c show that the resolving power is improved with the new method.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/42542]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
作者单位	1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 2.Beijing Inst Technol, Sch Life Sci, Beijing 100081, Peoples R China 3.Northeastern Univ, Sch Comp Sci & Engn, Shenyang 110819, Liaoning, Peoples R China
推荐引用方式 GB/T 7714	Tang, Yang,Li, Dayu,Cao, Dong,et al. Extracting biomolecule collision cross sections from FT-ICR mass spectral line shape[J]. TALANTA,2019,205:-.
APA	Tang, Yang,Li, Dayu,Cao, Dong,&Xu, Wei.(2019).Extracting biomolecule collision cross sections from FT-ICR mass spectral line shape.TALANTA,205,-.
MLA	Tang, Yang,et al."Extracting biomolecule collision cross sections from FT-ICR mass spectral line shape".TALANTA 205(2019):-.