A Nanozyme with Photo-Enhanced Dual Enzyme-Like Activities for Deep Pancreatic Cancer Therapy

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	A Nanozyme with Photo-Enhanced Dual Enzyme-Like Activities for Deep Pancreatic Cancer Therapy
	Li, Shanshan ; Shang, Lu 3; Xu, Bolong ; Wang, Shunhao 4; Gu, Kai ; Wu, Qingyuan ; Sun, Yun ; Zhang, Qinghua 2; Yang, Hailong ; Zhang, Fengrong
刊名	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
	2019-09-02
卷号	58 期号:36 页码:12624-12631
关键词	catalysis enzyme-like activity nanozymes photothermal therapy tumor therapy
ISSN号	1433-7851
英文摘要	Nanozymes have attracted extensive interest owing to their high stability, low cost and easy preparation, especially in the field of cancer therapy. However, the relatively low catalytic activity of nanozymes in the tumor microenvironment (TME) has limited their applications. Herein, we report a novel nanozyme (PtFe@Fe3O4) with dual enzyme-like activities for highly efficient tumor catalytic therapy. PtFe@Fe3O4 shows the intrinsic photothermal effect as well as photo-enhanced peroxidase-like and catalase-like activities in the acidic TME, thereby effectively killing tumor cells and overcoming the tumor hypoxia. Importantly, a possible photo-enhanced synergistic catalytic mechanism of PtFe@Fe3O4 was first disclosed. We believe that this work will advance the development of nanozymes in tumor catalytic therapy.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/42495]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
作者单位	1.Chinese Acad Sci, Inst Phys, Beijing Natl Lab Condensed Matter Phys, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 3.Beijing Univ Chem Technol, Beijing Adv Innovat Ctr Soft Matter Sci & Engn, State Key Lab Organ Inorgan Composites,Beijing La, Bionanomat & Translat Engn Lab,Beijing Key Lab Bi, Beijing 100029, Peoples R China 4.Chinese Acad Sci, Tech Inst Phys & Chem, Key Lab Photochem Convers & Optoelect Mat, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Li, Shanshan,Shang, Lu,Xu, Bolong,et al. A Nanozyme with Photo-Enhanced Dual Enzyme-Like Activities for Deep Pancreatic Cancer Therapy[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2019,58(36):12624-12631.
APA	Li, Shanshan.,Shang, Lu.,Xu, Bolong.,Wang, Shunhao.,Gu, Kai.,...&Liu, Huiyu.(2019).A Nanozyme with Photo-Enhanced Dual Enzyme-Like Activities for Deep Pancreatic Cancer Therapy.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,58(36),12624-12631.
MLA	Li, Shanshan,et al."A Nanozyme with Photo-Enhanced Dual Enzyme-Like Activities for Deep Pancreatic Cancer Therapy".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 58.36(2019):12624-12631.