Neuronal Signatures of Negative and Positive Schemas towards the Self and Others in Patients with Early Stage Schizophrenia

doi:10.30773/pi.2020.0335

	Neuronal Signatures of Negative and Positive Schemas towards the Self and Others in Patients with Early Stage Schizophrenia
	Shen, Jie 4; Shen, Guangfan 4; Kim, Woo-Sung 4; Tsogt, Uyanga 4; Liu, Congcong 4; Sui, Jing 2,3,5; Chung, Young-Chul 1,4,6
刊名	PSYCHIATRY INVESTIGATION
	2021-04-01
卷号	18 期号:4 页码:284-+
关键词	Negative schema Positive schema Schizophrenia fMRI
ISSN号	1738-3684
DOI	10.30773/pi.2020.0335
通讯作者	Chung, Young-Chul(chungyc@jbnu.ac.kr)
英文摘要	Objective The present study investigated the functional neuroanatomy underlying negative and positive schemas towards the self and others in patients with early stage schizophrenia spectrum disorders (SSDs) using a task-based fMRI procedure. Methods This study included 50 patients with SSDs and 52 controls. The schema-evoking task consisted of four active conditions and neutral condition. Differences in brain activation were compared between the two groups. Correlation analysis was performed between task-related activation and psychopathology. Results The SSD patients exhibited higher activity of the left middle and inferior frontal gyri under the negative-others minus neutral contrast as well as greater activation of the left superior and middle frontal gyri and right medial superior frontal gyrus under the positive-self minus neutral and positive-others minus neutral contrasts. Under the positive-others minus neutral contrast, negative correlation was observed between activity of the right inferior parietal gyrus and right angular and total score of the Positive and Negative Syndrome Scale (PANSS), whereas positive correlation between activity of the left middle cingulate gyrus and left/right precuneus and positive-others score of the Brief Core Schema Scales (BCSS). Conclusion The present findings suggest that the frontal brain regions of SSD patients are more sensitive to negative and positive schemas towards the self and/or others compared to those of controls. Psychiatry Investig 2021;18(4):284-294
资助项目	Korean Mental Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea[HL19C0015] ; Korea Health Technology R&D Project through the Korea Health Industry Development Institute - Ministry of Health & Welfare, Republic of Korea[HI18C2383]
WOS关键词	PSYCHOSIS ; FMRI ; REFLECTION ; DEPRESSION ; DELUSIONS ; SCALES ; BRAIN
WOS研究方向	Psychiatry
语种	英语
出版者	KOREAN NEUROPSYCHIATRIC ASSOC
WOS记录号	WOS:000645541600003
资助机构	Korean Mental Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea ; Korea Health Technology R&D Project through the Korea Health Industry Development Institute - Ministry of Health & Welfare, Republic of Korea
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/44660]
专题	自动化研究所_脑网络组研究中心
通讯作者	Chung, Young-Chul
作者单位	1.Jeonbuk Natl Univ, Biomed Res Inst, Jeonbuk Natl Univ Hosp, Res Inst Clin Med, Jeonju, South Korea 2.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 4.Jeonbuk Natl Univ, Dept Psychiat, Med Sch, 20 Geonji Ro, Jeonju 54907, South Korea 5.Univ Chinese Acad Sci, Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Beijing, Peoples R China 6.Jeonbuk Natl Univ Hosp, Dept Psychiat, Jeonju, South Korea
推荐引用方式 GB/T 7714	Shen, Jie,Shen, Guangfan,Kim, Woo-Sung,et al. Neuronal Signatures of Negative and Positive Schemas towards the Self and Others in Patients with Early Stage Schizophrenia[J]. PSYCHIATRY INVESTIGATION,2021,18(4):284-+.
APA	Shen, Jie.,Shen, Guangfan.,Kim, Woo-Sung.,Tsogt, Uyanga.,Liu, Congcong.,...&Chung, Young-Chul.(2021).Neuronal Signatures of Negative and Positive Schemas towards the Self and Others in Patients with Early Stage Schizophrenia.PSYCHIATRY INVESTIGATION,18(4),284-+.
MLA	Shen, Jie,et al."Neuronal Signatures of Negative and Positive Schemas towards the Self and Others in Patients with Early Stage Schizophrenia".PSYCHIATRY INVESTIGATION 18.4(2021):284-+.