Cingulum White Matter Integrity as a Mediator Between Harm Avoidance and Hostility

doi:10.1016/j.neuroscience.2021.02.031

	Cingulum White Matter Integrity as a Mediator Between Harm Avoidance and Hostility
	He, Yini 2,6; Li, Kaixin 2,7; Li, Jin 2; Wang, Jiaojian 6; Cheng, Nanhua 1; Xiao, Jing 1; Jiang, Tianzi 2,3,4,5,6
刊名	NEUROSCIENCE
	2021-05-01
卷号	461 页码:36-43
关键词	hostility white matter cingulum temperament harm avoidance mediation analysis
ISSN号	0306-4522
DOI	10.1016/j.neuroscience.2021.02.031
通讯作者	Jiang, Tianzi(jiangtz@nlpr.ia.ac.cn)
英文摘要	As a textbook manifestation of an aggressive attitude, hostility can pose a serious threat to both an individual?s life and the security of society at large. Past evidence suggests that some anxiety-related traits may be more prone to giving rise to hostility. However, many aspects of hostility, such as, determining the susceptible temperament for hostility, the neural basis of hostility, and the underlying mechanisms through which having a susceptible temperament generates hostility in a healthy brain, remain unclear. In this study, we sought to delve into these questions by assessing temperament and brain white matter integrity using self-report questionnaires and diffusion tensor imaging in a sizable sample of healthy adults (n = 357). First, we investigated the relationship between hostility and the four temperaments of the Cloninger model. Then, we investigated which white matter tracts were significantly correlated with hostility using a whole-brain analysis. Finally, we used a mediation analysis to explore the tripartite relationship between vulnerability temperament, the fractional anisotropy (FA) value of the white matter, and hostility. Our results suggest that a harm avoidance temperament may be susceptible to hostility and that the cingulum may be a key white matter region responsible for hostility. Based on these results, we developed a temperament-brain-attitude pathway showing how harm avoidance temperament could affect the brain and ultimately lead to hostility. ? 2021 Published by Elsevier Ltd on behalf of IBRO.
资助项目	National Key Research and Development Program of China[2017YFB1002502] ; National Key Research and Development Program of China[2017YFA0105203] ; Natural Science Foundation of China[91432302] ; Natural Science Foundation of China[31620103905] ; Natural Science Foundation of China[81501179] ; Science Frontier Program of the Chinese Academy of Sciences[QYZDJSSWSMC019] ; Beijing Brain Initiative of the Beijing Municipal Science & Technology Commission[Z161100000216152] ; Beijing Brain Initiative of the Beijing Municipal Science & Technology Commission[Z161100000216139] ; Beijing Brain Initiative of the Beijing Municipal Science & Technology Commission[Z171100000117002] ; Beijing Brain Initiative of the Beijing Municipal Science & Technology Commission[Z181100001518003] ; Beijing Brain Initiative of the Beijing Municipal Science & Technology Commission[Z181100001518004] ; Guangdong Pearl River Talents Plan[2016ZT06S220] ; Youth Innovation Promotion Association ; Beijing Advanced Discipline Fund
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000639337600004
资助机构	National Key Research and Development Program of China ; Natural Science Foundation of China ; Science Frontier Program of the Chinese Academy of Sciences ; Beijing Brain Initiative of the Beijing Municipal Science & Technology Commission ; Guangdong Pearl River Talents Plan ; Youth Innovation Promotion Association ; Beijing Advanced Discipline Fund
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/44275]
专题	自动化研究所_脑网络组研究中心
通讯作者	Jiang, Tianzi
作者单位	1.Capital Normal Univ, Sch Psychol, Beijing Key Lab Learning & Cognit, Beijing 100048, Peoples R China 2.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing 100190, Peoples R China 3.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia 4.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Inst Automat, Beijing 100190, Peoples R China 5.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing 100049, Peoples R China 6.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu 610054, Peoples R China 7.Harbin Univ Sci & Technol, Sch Mech & Power Engn, Harbin 150080, Peoples R China
推荐引用方式 GB/T 7714	He, Yini,Li, Kaixin,Li, Jin,et al. Cingulum White Matter Integrity as a Mediator Between Harm Avoidance and Hostility[J]. NEUROSCIENCE,2021,461:36-43.
APA	He, Yini.,Li, Kaixin.,Li, Jin.,Wang, Jiaojian.,Cheng, Nanhua.,...&Jiang, Tianzi.(2021).Cingulum White Matter Integrity as a Mediator Between Harm Avoidance and Hostility.NEUROSCIENCE,461,36-43.
MLA	He, Yini,et al."Cingulum White Matter Integrity as a Mediator Between Harm Avoidance and Hostility".NEUROSCIENCE 461(2021):36-43.